Chen Riken, Zhu Jinru, Yang Yitian, Liao Weifeng, Ye Weilong, Du Lianfang, Chen Mingdi, Zhang Yuan, Yao Weimin, Zheng Zhenzhen
The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong, China.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Sci Rep. 2025 Jan 11;15(1):1689. doi: 10.1038/s41598-025-86041-8.
Obstructive sleep apnea (OSA) often leads to complications in the elderly. This study compares the usefulness of five screening tools for OSA in elderly patients. Data from elderly patients diagnosed with OSA, collected from the Sleep Medicine Center of the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2017, is analyzed. The sensitivity, specificity, predictive values, area under the curve (AUC), and diagnostic odds ratio (DOR) of the five screening tools are computed and compared. 273 elderly patients with suspected OSA are included, of whom 189 are male (69.2%). The Berlin Questionnaire has an AUC of 0.670 (95%CI: 0.611-0.725) at different cut-off points. The sensitivity and specificity of the Berlin Questionnaire are noticeably high at 0.653 (0.587-0.719) and 0.608 (0.497-0.719), 0.699 (0.621-0.776) and 0.533 (0.449-0.616), and 0.803 (0.713-0.892) and 0.503 (0.433-0.572) when the AHI is 5, 15, and 30 times/hour, respectively. The GOAL Questionnaire has the highest DOR at AHI cut-off points of 5 and 15 times/hour, while Berlin has the highest DOR at an AHI cut-off point of 30 times/hour. Comprehensive use of these five screening questionnaires for suspected OSA in elderly patients aged 60 years and older is valuable and worth promoting among the elderly population.
阻塞性睡眠呼吸暂停(OSA)在老年人中常引发并发症。本研究比较了五种OSA筛查工具对老年患者的有效性。分析了2012年1月至2017年6月从广州医科大学附属第一医院睡眠医学中心收集的老年OSA确诊患者的数据。计算并比较了这五种筛查工具的敏感性、特异性、预测值、曲线下面积(AUC)和诊断比值比(DOR)。纳入了273例疑似OSA的老年患者,其中189例为男性(69.2%)。柏林问卷在不同切点的AUC为0.670(95%CI:0.611 - 0.725)。当呼吸暂停低通气指数(AHI)分别为5次/小时、15次/小时和30次/小时时,柏林问卷的敏感性和特异性显著较高,分别为0.653(0.587 - 0.719)和0.608(0.497 - 0.719)、0.699(0.621 - 0.776)和0.533(0.449 - 0.616)、0.803(0.713 - 0.892)和0.503(0.433 - 0.572)。在AHI切点为5次/小时和15次/小时时,GOAL问卷的DOR最高,而在AHI切点为30次/小时时,柏林问卷的DOR最高。综合使用这五种筛查问卷对60岁及以上疑似OSA的老年患者具有重要价值,值得在老年人群中推广。