Yang Chunli, Lu Bin, Lin Zheng
Department of Clinical Medicine, Jining Medical University, Jining, China.
J Med Case Rep. 2025 Jan 11;19(1):13. doi: 10.1186/s13256-024-05020-1.
Superficial acral fibromyxoma is a noncancerous, benign tumor of soft tissue with an unidentified origin. Occurrences of abnormalities on the palm are less frequently documented.
A 47-year-old East Asian woman presented with a palm tumor on her left knuckle that had been present for 4 months. Four months prior to treatment, a reddish nodule appeared at the site due to continuous friction, but the patient did not pay attention to it. Upon physical examination, a pale-reddish nodule measuring approximately 0.8 × 0.8 cm was observed on the flexion side of the fourth metacarpophalangeal joint of the left hand. The nodule was nearly round, exhibited distinct margins, featured slight surface keratosis, and displayed a collar-like alteration at its periphery. The stroma showed significant fibrous proliferation and a myxoid matrix. The cellular composition consisted primarily of spindle-shaped fibroblasts, which were locally arranged in bundles within the stroma. Sparse slender blood vessels were distributed along with observed red blood cell extravasation. Immunohistochemistry of the tumor showed CD34 (+), CD99 (-), desmin (-), epithelial membrane antigen (-). Extensive resection of the mass was performed.
A rounded mass on the palm of the hand may be superficial acral fibromyxoma. The optimal approach for treating superficial acral fibromyxoma involves complete surgical removal of the mass followed by postoperative monitoring.
浅表性肢端纤维黏液瘤是一种起源不明的非癌性软组织良性肿瘤。手掌部出现异常的病例报道较少。
一名47岁的东亚女性，其左手指关节处出现手掌肿瘤，已存在4个月。治疗前4个月，该部位因持续摩擦出现一个红色小结节，但患者未予以重视。体格检查时，在左手第四掌指关节的屈曲侧观察到一个淡红色结节，大小约为0.8×0.8厘米。结节近乎圆形，边界清晰，表面有轻微角化，周边呈领圈样改变。间质显示明显的纤维增生和黏液样基质。细胞成分主要为梭形成纤维细胞，在间质内局部呈束状排列。可见稀疏的细长血管伴红细胞外渗。肿瘤的免疫组化显示CD34（+）、CD99（-）、结蛋白（-）、上皮膜抗原（-）。对肿块进行了广泛切除。
手掌部的圆形肿块可能是浅表性肢端纤维黏液瘤。治疗浅表性肢端纤维黏液瘤的最佳方法是完整手术切除肿块并进行术后监测。
