一项病例对照研究表明，伴有共病焦虑的精神病性谱系障碍是帕金森病的诱发因素。
Psychotic-Spectrum Disorders With Comorbid Anxiety Are Predisposing Factors for Parkinson's Disease in a Case-Control Study.
作者信息
Shvartsur Anna, Peterman Kelli, Ramalingam Nirmala D, Eyal Roy, Khandhar Suketu, Medina Michel, Hirschtritt Matthew E
机构信息
Department of Psychiatry, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
出版信息
Perm J. 2025 Mar 14;29(1):102-107. doi: 10.7812/TPP/24.131. Epub 2025 Jan 12.
BACKGROUND
Multiple studies have demonstrated associations between psychiatric conditions and Parkinson's disease (PD) development; fewer have examined psychotic-spectrum disorders and PD development.
OBJECTIVE
The objective was to assess the prevalence of psychotic-spectrum disorders with and without depression and anxiety preceding a PD diagnosis.
METHODS
In this retrospective, case-control study of adults > 60 years of age, cases were identified by PD diagnosis and controls were identified in a 3:1 ratio by ambulatory encounter from 2015 to 2020. Psychiatric conditions were identified by diagnosis code up to 5 years prior to the index date. Conditional logistic regression was conducted to assess associations.
RESULTS
Among 13,998 patients, the odds of PD were 76% (95% confidence interval = 1.39-2.22) higher among those with psychotic-spectrum diagnoses. An additional anxiety diagnosis was associated with 166% (95% confidence interval = 1.35-5.25) higher odds of PD.
CONCLUSIONS
Awareness of psychiatric conditions, including psychotic-spectrum disorders with comorbid anxiety, can stratify individuals at higher risk of developing PD.
背景
多项研究已证明精神疾病与帕金森病（PD）的发生之间存在关联；较少有研究探讨精神病性谱系障碍与PD发生之间的关系。
目的
目的是评估在PD诊断之前伴有和不伴有抑郁及焦虑的精神病性谱系障碍的患病率。
方法
在这项针对60岁以上成年人的回顾性病例对照研究中，通过PD诊断确定病例，并在2015年至2020年期间以3:1的比例通过门诊就诊确定对照。通过索引日期前5年内的诊断代码确定精神疾病。进行条件逻辑回归以评估关联。
结果
在13998名患者中，患有精神病性谱系诊断的患者患PD的几率高76%（95%置信区间=1.39 - 2.22）。额外的焦虑诊断与患PD的几率高166%（95%置信区间=1.35 - 5.25）相关。
结论
了解精神疾病，包括伴有共病焦虑的精神病性谱系障碍，可对患PD风险较高的个体进行分层。
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