Shan Yongzhuang, Zhai Wenshan, Hou Yayun, Li Guangming
Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Jiangsu, China/Department of Anesthesiology, Huai'an Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu, China.
Department of Anesthesiology, Huai'an Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu, China.
Pak J Pharm Sci. 2024 Nov-Dec;37(6):1391-1399.
Traditional sedatives like Propofol can lead to adverse effects. This study compares the safety and efficacy of Ciprofol monotherapy versus combined Propofol for painless gastroscopy. Patients underwent painless gastroscopy at our hospital from January 2023 to December 2023 were studied. Sedation quality, adverse events, patient satisfaction, cognitive function, pain, anxiety, gastrointestinal side effects and endoscopic quality and so on was recorded and assessed. A retrospective analysis was conducted on patients undergoing painless gastroscopy from January to December 2023. Participants (n = 200) were categorized into Ciprofol (n = 102) and Combined Propofol (n = 98) groups. The Ciprofol group exhibited longer sedation onset (4.35 ± 1.71 min) but significantly quicker recovery (12.64 ± 4.54 min) compared to the combined group. Adverse events of nausea (2.94% vs 10.20%, p = 0.037) and vomiting (1.96% vs 9.18%, p = 0.025) were less frequent in the Ciprofol group, although satisfaction scores were similar between groups. Cognitive function, pain, anxiety levels and gastrointestinal side effects was comparable. Endoscopy quality measures showed no significant differences. Cyclophenol monotherapy is a viable alternative to combine Propofol, offering a reduced incidence of adverse effects and quicker recovery without compromising procedure quality or cognitive outcomes.
像丙泊酚这样的传统镇静剂可能会导致不良反应。本研究比较了丙泊酚单药治疗与联合丙泊酚用于无痛胃镜检查的安全性和有效性。对2023年1月至2023年12月在我院接受无痛胃镜检查的患者进行了研究。记录并评估了镇静质量、不良事件、患者满意度、认知功能、疼痛、焦虑、胃肠道副作用和内镜检查质量等。对2023年1月至12月接受无痛胃镜检查的患者进行了回顾性分析。参与者（n = 200）被分为丙泊酚组（n = 102）和联合丙泊酚组（n = 98）。与联合组相比，丙泊酚组的镇静起效时间更长（4.35 ± 1.71分钟），但恢复明显更快（12.64 ± 4.54分钟）。丙泊酚组恶心（2.94%对10.20%，p = 0.037）和呕吐（1.96%对9.18%，p = 0.
