Pahima Hadas Tamar, Dwyer Daniel F
Jeff and Penny Vinik Center for Allergic Disease Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
Jeff and Penny Vinik Center for Allergic Disease Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
J Allergy Clin Immunol. 2025 Apr;155(4):1115-1123. doi: 10.1016/j.jaci.2024.12.1092. Epub 2025 Jan 10.
Mast cells (MCs) are heterogeneous tissue-resident effector cells that are thought to play central roles in allergic inflammatory disease, yet the degree of heterogeneity and nature of these roles has remained elusive. In recent years, advances in tissue culture systems, preclinical mouse models, and the continued spread of single-cell RNA sequencing have greatly advanced our understanding of MC phenotypes in health and disease. These approaches have identified novel interactions of MC subsets with immune cells, neurons, and tissue structural cells, changing our understanding of how MCs both drive and help resolve tissue inflammation, reshape tissue microenvironments, and influence host behavior. This review addresses key studies from 2022 to 2024 that have advanced our understanding of MC biology in mice and humans.
肥大细胞（MCs）是一类异质性的组织驻留效应细胞，被认为在过敏性炎症疾病中起核心作用，但其异质性程度和这些作用的本质仍不清楚。近年来，组织培养系统、临床前小鼠模型的进展以及单细胞RNA测序的不断普及，极大地推进了我们对健康和疾病状态下MC表型的理解。这些方法确定了MC亚群与免疫细胞、神经元和组织结构细胞之间的新型相互作用，改变了我们对MC如何驱动和帮助解决组织炎症、重塑组织微环境以及影响宿主行为的理解。本综述探讨了2022年至2024年的关键研究，这些研究推进了我们对小鼠和人类MC生物学的理解。
