[纳米药物递送技术在克服肺癌耐药性中的应用]
[Application of Nano-drug Delivery Technology in Overcoming Drug Resistance in Lung Cancer].
作者信息
Lu Yingchun, Wang Chunyu, Liu Bin
机构信息
School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2024 Nov 20;27(11):864-872. doi: 10.3779/j.issn.1009-3419.2024.101.30.
Lung cancer is one of the most malignant tumor, representing a significant threat to human health. In China, its mortality rate is the highest among all malignant tumors. The occurrence of drug resistance has resulted in unfavourable prognosis for patients with lung cancer, and overcoming drug resistance is a significant challenge that needs to be addressed. Nano-drug delivery technology has been an important approach to overcome drug resistance in lung cancer. Targeting to the mechanisms of drug resistance, by enabling the combined delivery of drugs, increasing the efficiency of drug delivery and improving the targeting and safety of drugs, nano-drug delivery technology offers a novel approach to tackling drug resistance in lung cancer. This paper describes the current status of lung cancer treatment, mechanisms of drug resistance, strategies to overcome drug resistance, and the application of nanotechnology in the diagnosis and treatment of lung cancer. In addition, it summarizes the recent research progress on the application of nano-drug delivery technology to overcome drug resistance in lung cancer. Finally, the current prospects and challenges of nano-drug delivery technology are discussed. .
肺癌是最具恶性的肿瘤之一，对人类健康构成重大威胁。在中国，其死亡率在所有恶性肿瘤中最高。耐药性的出现导致肺癌患者预后不良，克服耐药性是一个需要解决的重大挑战。纳米药物递送技术一直是克服肺癌耐药性的重要途径。通过针对耐药机制，实现药物的联合递送，提高药物递送效率，改善药物的靶向性和安全性，纳米药物递送技术为解决肺癌耐药性提供了一种新方法。本文介绍了肺癌治疗的现状、耐药机制、克服耐药性的策略以及纳米技术在肺癌诊断和治疗中的应用。此外，还总结了纳米药物递送技术在克服肺癌耐药性方面的最新研究进展。最后，讨论了纳米药物递送技术目前的前景和挑战。
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