豚鼠巨噬细胞和中性粒细胞对可溶性免疫复合物的摄取与降解。
The ingestion and degradation of soluble immune complexes by guinea-pig macrophages and neutrophils.
作者信息
Leslie R G, Coupland K
出版信息
Immunology. 1985 Apr;54(4):811-9.
The kinetics of ingestion and degradation of guinea-pig IgG2-containing soluble immune complexes by guinea-pig macrophages and neutrophils have been compared and aspects of the biochemical control of these events in neutrophils have been investigated using a selection of inhibitors. Differences were observed between the macrophages and neutrophils in the stability of complex attachment to their surface membranes, in the rates and modes of complex ingestion and in the relative and absolute rates of digestion of the antibody and antigen components within the complexes. On the other hand, the response of the neutrophils to different inhibitors was broadly similar to that previously observed with the macrophages. The differences observed are discussed and the importance of the Fc-receptor expression in determining these differences is assessed.
对豚鼠巨噬细胞和中性粒细胞摄取和降解含豚鼠IgG2的可溶性免疫复合物的动力学进行了比较，并使用一系列抑制剂研究了中性粒细胞中这些过程的生化控制方面。观察到巨噬细胞和中性粒细胞在复合物与它们表面膜的附着稳定性、复合物摄取的速率和方式以及复合物内抗体和抗原成分的相对和绝对消化速率方面存在差异。另一方面，中性粒细胞对不同抑制剂的反应与先前在巨噬细胞中观察到的反应大致相似。讨论了观察到的差异，并评估了Fc受体表达在决定这些差异中的重要性。
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