利多卡因对腹膜巨噬细胞处理可溶性免疫聚集体和免疫复合物的影响。
The effect of lidocaine on the processing of soluble immune aggregates and immune complexes by peritoneal macrophages.
作者信息
Hijlstra A, Van Dorp W, Daha M R, Leslie G Q
出版信息
Immunology. 1980 Sep;41(1):237-44.
Abstract
In a search for new techniques which would specifically identify the various steps of the handling of immune complexes by macrophages the local anaesthetic, lidocaine, was investigated. Lidocaine was shown to inhibit selectively the digestion of immune complexes and immunoglobulin aggregates by macrophages whereas it had little effect on the binding or ingestion steps. Due to the reversible inhibitory effect of lidocaine, this drug may be used in future studies to assess the role of extracellular stimuli on the fate of intracellular immune complexes.
摘要
为了寻找能够特异性识别巨噬细胞处理免疫复合物各个步骤的新技术，对局部麻醉剂利多卡因进行了研究。结果表明，利多卡因可选择性抑制巨噬细胞对免疫复合物和免疫球蛋白聚集体的消化，而对结合或摄取步骤影响很小。由于利多卡因具有可逆的抑制作用，该药物未来可用于评估细胞外刺激对细胞内免疫复合物命运的作用。
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