Crocco Marco, Malerba Federica, Calvi Angela, Zampatti Noemi, Valitutti Francesco, Pisciotta Livia, Borgarelli Consuelo, Montuori Monica, Oliva Salvatore, Catassi Giulia, Borghini Raffaele, Trovato Chiara Maria, Ferretti Francesca, Felici Enrico, Roviglione Barbara, Monzani Alice, Terzi Chiara, Caldonazzi Federico, Bortolotti Valentina, Cavalli Elena, Cozzali Rita, Illiceto Maria Teresa, Citrano Michele, Graziano Francesco, Romano Claudio, Laganà Francesca, Auricchio Renata, Ferro Jacopo, Gandullia Paolo, Proietti Stefania, Bonassi Stefano
Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132 Genoa, Italy.
Dig Liver Dis. 2025 Apr;57(4):833-841. doi: 10.1016/j.dld.2024.12.020. Epub 2025 Jan 12.
In pediatric patients, celiac disease (CD) may influence the health-related quality of life (HRQoL).
The study aimed to assess HRQoL and further characterise the clinical factors associated with reduced HRQoL, in a large multicenter pediatric cohort with CD.
The disease-specific questionnaire CD Dutch Questionnaire (CDDUX) and the generic questionnaire Paediatric Quality of Life Inventory (PedsQL) were used to assess the HRQoL. Clinical and sociodemographic characteristics were analyzed, univariate and multivariate analysis were conducted.
Eleven different Italian pediatric centers and 871 families were involved. Mean age at interview was 12.9 ± 2.9 years. The mean total CDDUX score of CD patients was 47.1 ± 18.8, revealing a neutral HRQoL (47.1 ± 18.8), and a good to very good HRQoL according to the PedsQL (81.4 ± 12.6), parents indicated lower scores (p = 0.03) with both questionnaires (CDDUX 45.1 ± 18.6 and PedsQL 79.9 ± 14.5). Patients with lower HRQoL were mainly female, living in Northern Italy, with lower parent's education level and non-biopsy diagnosis of CD. In multivariate analysis, the main predictor of lower CDDUX score was non-biopsy diagnosis.
The HRQoL in a large cohort of Italian children is reported as neutral-good. This indicates a high level of adaptive behaviors in response to the daily challenges of CD. Parents tend to underestimate their children's HRQoL. Specific clinical factors, including non-biopsy diagnosis, may be associated to lower HRQoL.
在儿科患者中，乳糜泻（CD）可能会影响健康相关生活质量（HRQoL）。
本研究旨在评估一大群患有CD的多中心儿科队列中的HRQoL，并进一步描述与HRQoL降低相关的临床因素。
使用疾病特异性问卷《荷兰乳糜泻问卷》（CDDUX）和通用问卷《儿童生活质量量表》（PedsQL）来评估HRQoL。分析临床和社会人口学特征，进行单变量和多变量分析。
涉及11个不同的意大利儿科中心和871个家庭。访谈时的平均年龄为12.9±2.9岁。CD患者的CDDUX总评分平均为47.1±18.8，显示HRQoL为中性（47.1±18.8），根据PedsQL显示HRQoL为良好至非常好（81.4±12.6），父母表示两份问卷的得分较低（p = 0.03）（CDDUX为45.1±18.6，PedsQL为79.9±14.5）。HRQoL较低的患者主要为女性，居住在意大利北部，父母教育水平较低且为非活检诊断的CD。在多变量分析中，CDDUX得分较低的主要预测因素是非活检诊断。
据报道，一大群意大利儿童的HRQoL为中性至良好。这表明在应对CD的日常挑战时具有较高水平的适应行为。父母往往低估孩子的HRQoL。特定的临床因素，包括非活检诊断，可能与较低的HRQoL相关。
