Uter Wolfgang, Andersen Klaus Ejner, Brans Richard, Bruze Magnus, Schubert Steffen, Gonçalo Margarida
Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander Universität Erlangen/Nürnberg, Erlangen, Germany.
Department of Dermatology and Allergy, Odense University Hospital, and Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Contact Dermatitis. 2025 Apr;92(4):251-260. doi: 10.1111/cod.14750. Epub 2025 Jan 12.
Since its inception in 1980, the MOHL index (% patients who are male, have occupational, hand, or leg dermatitis, respectively) and its later evolutions until the presently used MOAHLFA(P) index (adding % patients with atopic dermatitis, face dermatitis, age 40+ years and positive reaction(s) to ≥ 1 baseline series allergen) have been intended to convey important demographic and clinical information on the patients patch tested in a certain area and time, aiding the interpretation of the observed spectrum of sensitisation.
To examine the current usage of the MOAHLFA(P) index and suggest consolidated definitions for its single items.
A title/abstract search in Medline identified publications mentioning the evolving acronyms. A Delphi-like survey among contact dermatitis experts collected agreement with suggested definitions.
The search term 'MOAHLFA' was used in 35 publications from a broad geographical origin. More than 80% of the 24 participants of the survey (65% response) agreed on maintaining to use (i) sex for the 'M' criterion, (ii) occupation-related dermatitis irrespective of medicolegal definitions for the 'O', (iii) atopic dermatitis (but not rhinitis or asthma) for the 'A'. The possibility to use more than one site among 'H', 'L' and 'F' and a more detailed description of age distribution were favoured, and the difficult interpretability of the 'P' measure was highlighted.
The 'classical' MOAHLFA(P) index may be extended. Some aspects, notably atopic dermatitis, need further standardisation.
自1980年创立以来,MOHL指数(分别为男性、职业性、手部或腿部皮炎患者的百分比)及其后来的演变版本,直至目前使用的MOAHLFA(P)指数(增加了特应性皮炎、面部皮炎、40岁以上患者以及对≥1种基线系列变应原呈阳性反应的患者的百分比),旨在传达特定地区和时间内接受斑贴试验患者的重要人口统计学和临床信息,有助于对观察到的致敏谱进行解释。
研究MOAHLFA(P)指数的当前使用情况,并为其单个项目提出统一的定义。
在Medline中进行标题/摘要搜索,以确定提及不断演变的首字母缩略词的出版物。在接触性皮炎专家中进行类似德尔菲法的调查,收集对建议定义的认同情况。
搜索词“MOAHLFA”在来自广泛地理区域的35篇出版物中被使用。调查的24名参与者中超过80%(回复率65%)同意继续使用:(i) “M”标准为性别;(ii) “O”为与职业相关的皮炎,不考虑法医学定义;(iii) “A”为特应性皮炎(而非鼻炎或哮喘)。大家赞成在“H”“L”和“F”中可以使用多个部位,并对年龄分布进行更详细的描述,同时强调了“P”指标难以解释。
“经典的”MOAHLFA(P)指数可能需要扩展。某些方面,尤其是特应性皮炎,需要进一步标准化。