[大剂量甲氨蝶呤治疗后急性毒性的管理]
[(Management of acute toxicity after high dose methotrexate therapy)].
作者信息
Urban C, Mutz I, Kotz R, Krisch K
出版信息
Onkologie. 1979 Dec;2(6):238-42. doi: 10.1159/000214623.
PMID:398013
Abstract
A 13-year-old girl with osteosarcoma and pulmonary metastases developed life-threatening renal toxicity, encephalopathy, and bone marrow failure following high dose methotrexate therapy. After successful treatment, high dose methotrexate therapy was continued without further problems. Recommendations for the prevention and the current management of methotrexate toxicity are discussed.
摘要
一名患有骨肉瘤并伴有肺转移的13岁女孩在接受大剂量甲氨蝶呤治疗后出现了危及生命的肾毒性、脑病和骨髓衰竭。成功治疗后，继续进行大剂量甲氨蝶呤治疗且未再出现问题。文中讨论了甲氨蝶呤毒性的预防及当前管理建议。
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