Ridgway D, Renholds D C, Neerhout R C, Wolff L J
Cancer. 1980 Dec 15;46(12):2571-2. doi: 10.1002/1097-0142(19801215)46:12<2571::aid-cncr2820461206>3.0.co;2-w.
A 14-year-old received a six-hour infusion of methotrexate (71/2 g/M2) with vincristine (2 mg) and citrovorum rescue according to a standard protocol for adjunctive chemotherapy of osteogenic sarcoma. Signs of mild vincristine toxicity occurred from 2-5 days following the infusion; these including jaw pain, decreases in deep tendon reflexes, and a transient ileus. Clearance of serum methotrexate was delayed during the period of ileus and severe methotrexate toxicity was observed.
一名14岁的患者按照骨肉瘤辅助化疗的标准方案接受了6小时的甲氨蝶呤（71/2 g/M2）输注，并同时输注了长春新碱（2 mg）以及进行了亚叶酸钙解救。输注后2至5天出现了轻度长春新碱毒性的体征；这些体征包括颌部疼痛、深部腱反射减弱以及短暂性肠梗阻。肠梗阻期间血清甲氨蝶呤的清除延迟，并且观察到了严重的甲氨蝶呤毒性。
