新型冠状病毒肺炎重症监护入院对英国患者的心理影响

Psychological impact of an intensive care admission for COVID-19 on patients in the United Kingdom.

作者信息

Waite Alicia Ac, Cherry Mary Gemma, Brown Stephen L, Williams Karen, Boyle Andrew J, Johnston Brian W, Jones Christina, Fisher Peter, Welters Ingeborg D

机构信息

Intensive Care Unit, Royal Liverpool University Hospital, Liverpool, UK.

Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

出版信息

J Intensive Care Soc. 2025 Jan 11;26(1):11-20. doi: 10.1177/17511437241312113. eCollection 2025 Feb.

DOI:10.1177/17511437241312113

PMID:39801629

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11724402/

Abstract

BACKGROUND

The psychological impact of surviving an admission to an intensive care unit (ICU) with COVID-19 is uncertain. The objective of the study was to assess the prevalence of anxiety, depression and post-traumatic stress disorder (PTSD) symptoms in ICU survivors treated for COVID-19 infection, and identify risk factors for psychological distress.

METHODS

This observational study was conducted at 52 ICUs in the United Kingdom. Participants, treated for COVID-19 infection during an ICU admission of ⩾24 h, were recruited post-ICU discharge. Self-report questionnaires were completed at 3, 6 and/or 12 months. Symptoms of anxiety and depression were identified using the Hospital Anxiety and Depression Scale. PTSD was assessed using the Impact of Events Scale-6. Demographic, clinical, physical and psychosocial factors were considered as putative predictors of psychological distress.

RESULTS

1620 patients provided consent and 1258 (77.7%) responded to at least one questionnaire, with responses at 3 months ( = 426), 6 months ( = 656) and 12 months ( = 1050) following ICU admission. The following prevalence rates were found at 3, 6 and 12 months, respectively: anxiety in 28.8% (95% CI 24.6-33.1), 30.4% (95% CI 27.0-33.8) and 29.3% (95% CI 26.5-32.1); depression in 25.1% (21.0-29.3), 25.9% (22.7-29.3) and 24.0% (21.5-26.6); and PTSD in 43.5% (38.8-48.2), 44.3% (40.6-48.0) and 43.2% (40.2-46.1) of patients. Risk factors for psychological distress included a previous mental health diagnosis, unemployment or being on sick leave, and a history of asthma or COPD.

CONCLUSION

Clinically significant symptoms of anxiety, depression and PTSD were common and persisted up to 12 months post-ICU discharge.

摘要

背景

新冠肺炎患者在重症监护病房（ICU）救治成功后的心理影响尚不确定。本研究的目的是评估因新冠肺炎感染接受治疗的ICU幸存者中焦虑、抑郁和创伤后应激障碍（PTSD）症状的发生率，并确定心理困扰的风险因素。

方法

本观察性研究在英国的52个ICU进行。在ICU住院≥24小时期间因新冠肺炎感染接受治疗的参与者在ICU出院后被招募。在3个月、6个月和/或12个月时完成自我报告问卷。使用医院焦虑抑郁量表识别焦虑和抑郁症状。使用事件影响量表-6评估PTSD。人口统计学、临床、身体和心理社会因素被视为心理困扰的假定预测因素。

结果

1620名患者提供了同意书，1258名（77.7%）至少对一份问卷做出了回应，分别在ICU入院后3个月（n = 426）、6个月（n = 656）和12个月（n = 1050）时做出回应。在3个月、6个月和12个月时分别发现以下发生率：焦虑为28.8%（95%CI 24.6-33.1）、30.4%（95%CI 27.0-33.8）和29.3%（95%CI 26.5-32.1）；抑郁为25.1%（21.0-29.3）、25.9%（22.7-29.3）和24.0%（21.5-26.6）；PTSD在患者中分别为43.5%（38.8-48.2）、44.3%（40.6-48.0）和43.2%（40.2-46.1）。心理困扰的风险因素包括既往心理健康诊断、失业或病假以及哮喘或慢性阻塞性肺疾病史。