Carlier François M, Dumonceaux Michel, Planté-Bordeneuve Thomas, Evrard Patrick, Marchand Eric, Belhaj Asmae, Rondelet Benoît, Demeure Fabian
Lung Transplant Centre, CHU Mont-Godinne UCL Namur, Yvoir, Belgium.
Department of Pneumology, CHU Mont-Godinne UCL Namur, Yvoir, Belgium.
Heliyon. 2024 Dec 14;11(1):e41222. doi: 10.1016/j.heliyon.2024.e41222. eCollection 2025 Jan 15.
Post-capillary hypertension resulting from mitral regurgitation is typically considered a contraindication for single lung transplantation due to heightened risks of primary graft dysfunction. This case report highlights a 66-year-old COPD patient with severe mitral regurgitation who was deemed ineligible for surgical mitral replacement. As an alternative, transcatheter mitral valve replacement was successfully performed, resulting in the normalization of pulmonary artery pressures. Consequently, the patient became eligible for single lung transplantation, which was conducted successfully in the subsequent months. Eighteen months post-lung transplantation, the patient now experiences a normal functional status and excellent lung function. In conclusion, transcatheter mitral valve replacement appears to be a safe alternative to surgery for normalizing post-capillary pulmonary hypertension in patients with chronic respiratory diseases. This approach could potentially facilitate lung transplantation (LTx) in eligible candidates.
由于原发性移植物功能障碍风险增加，二尖瓣反流导致的毛细血管后高血压通常被视为单肺移植的禁忌证。本病例报告重点介绍了一名66岁的慢性阻塞性肺疾病（COPD）患者，该患者患有严重二尖瓣反流，被认为不适合进行二尖瓣置换手术。作为替代方案，成功实施了经导管二尖瓣置换术，使肺动脉压力恢复正常。因此，该患者符合单肺移植条件，并在随后几个月成功进行了移植。肺移植术后18个月，患者目前功能状态正常，肺功能良好。总之，经导管二尖瓣置换术似乎是一种安全的手术替代方案，可使慢性呼吸系统疾病患者的毛细血管后肺动脉高压恢复正常。这种方法可能有助于符合条件的患者进行肺移植（LTx）。
