Abdolvand Mitra, Radanfar Roya, Sepaskhah Mozhdeh, Sari Aslani Fatemeh, Akbarzadeh Jahromi Mojgan
Department of Dermatology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran.
Molecular Dermatology Research Center, Department of Dermatology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran.
Clin Case Rep. 2025 Jan 10;13(1):e70100. doi: 10.1002/ccr3.70100. eCollection 2025 Jan.
Follicular porokeratosis (FPK) is a rare subtype of porokeratosis. Follicular porokeratosis mainly occurs in men and may be localized or diffuse. Involvement of the scalp is rarely reported, and we found only one case of alopecia due to scalp FPK. Diabetes mellitus has not been reported in association with FPK We report a 35-year-old diabetic woman that presented with brown follicular keratotic papules and spicules involving the scalp, face, trunk, and extremities, accompanied by scalp alopecia. The differential diagnoses were lichen planopilaris, papular eczema, and phrynoderma. Histopathologic examination of skin punch biopsies revealed the follicle-centered cornoid lamella as the feature of FPK. The patient was treated with oral isotretinoin, and the lesions improved partially within 6 weeks of follow-up. Follicular porokeratosis might be considered among the differential diagnoses of keratotic papules (with or without spicules) and in the cases of alopecia with keratotic papules. Diabetes mellitus may be associated with FPK.
毛囊性汗孔角化症（FPK）是汗孔角化症的一种罕见亚型。毛囊性汗孔角化症主要发生于男性，可为局限性或播散性。头皮受累的情况鲜有报道，我们仅发现1例因头皮毛囊性汗孔角化症导致的脱发。糖尿病与毛囊性汗孔角化症的关联尚未见报道。我们报告1例35岁的糖尿病女性，其头皮、面部、躯干和四肢出现褐色毛囊性角化性丘疹及棘状突起，并伴有头皮脱发。鉴别诊断包括扁平苔藓样毛发角化病、丘疹性湿疹和蟾皮病。皮肤打孔活检的组织病理学检查显示以毛囊为中心的鸡眼样板层，这是毛囊性汗孔角化症的特征。该患者接受口服异维A酸治疗，在随访的6周内皮损部分改善。在角化性丘疹（有或无棘状突起）的鉴别诊断以及伴有角化性丘疹的脱发病例中，可能需要考虑毛囊性汗孔角化症。糖尿病可能与毛囊性汗孔角化症有关。
