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滤泡性角化不良症:四例新病例。

Follicular porokeratosis: four new cases.

机构信息

Department of Dermatology, Warwick Hospital, Warwick, Warwickshire, UK.

Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.

出版信息

Clin Exp Dermatol. 2017 Dec;42(8):881-886. doi: 10.1111/ced.13195. Epub 2017 Jul 27.

Abstract

Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). In recent years, a proposed new subtype, follicular porokeratosis (FP_, has been described, in which the cornoid lamella are exclusively located in the follicular ostia. We present four new cases that showed typical histological features of FP.

摘要

角化病是一种角化异常的疾病,其临床特征为存在环形斑块,周围有角化嵴。临床变异型包括线状、播散性浅表光化性、疣状/肥厚性、播散性发疹性、掌跖部和 Mibelli 角化病(一个或两个具有萎缩中心和沟状角化缘的典型斑块)。所有这些亚型都具有角蛋白样层的组织学特征,其特征是“堆积”的角化不良柱,颗粒层局部缺失,以及发育不良(上层棘状层过早角化的细胞)。近年来,描述了一种新的拟议亚型,即毛囊角化病(FP_),其中角蛋白样层仅位于毛囊口。我们介绍了四个新病例,这些病例显示了 FP 的典型组织学特征。

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