Department of Dermatology, Warwick Hospital, Warwick, Warwickshire, UK.
Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.
Clin Exp Dermatol. 2017 Dec;42(8):881-886. doi: 10.1111/ced.13195. Epub 2017 Jul 27.
Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). In recent years, a proposed new subtype, follicular porokeratosis (FP_, has been described, in which the cornoid lamella are exclusively located in the follicular ostia. We present four new cases that showed typical histological features of FP.
角化病是一种角化异常的疾病，其临床特征为存在环形斑块，周围有角化嵴。临床变异型包括线状、播散性浅表光化性、疣状/肥厚性、播散性发疹性、掌跖部和 Mibelli 角化病（一个或两个具有萎缩中心和沟状角化缘的典型斑块）。所有这些亚型都具有角蛋白样层的组织学特征，其特征是“堆积”的角化不良柱，颗粒层局部缺失，以及发育不良（上层棘状层过早角化的细胞）。近年来，描述了一种新的拟议亚型，即毛囊角化病（FP_），其中角蛋白样层仅位于毛囊口。我们介绍了四个新病例，这些病例显示了 FP 的典型组织学特征。
