van Velzen Laura S, Colic Lejla, Ceja Zuriel, Dauvermann Maria R, Villa Luca M, Savage Hannah S, Toenders Yara J, Dehestani Niousha, Zhu Alyssa H, Campos Adrian I, Salminen Lauren E, Agartz Ingrid, Alexander Nina, Ayesa-Arriola Rosa, Ballard Elizabeth D, Banaj Nerisa, Barkhau Carlotta, Başgöze Zeynep, Bauer Jochen, Benedetti Francesco, Berger Klaus, Besteher Bianca, Brosch Katharina, Canal-Rivero Manuel, Cervenka Simon, Colle Romain, Connolly Colm G, Corruble Emmanuelle, Courtet Philippe, Couvy-Duchesne Baptiste, Crespo-Facorro Benedicto, Cullen Kathryn R, Dannlowski Udo, Deverdun Jeremy, Diaz-Zuluaga Ana M, Dietze Lorielle M F, Evans Jennifer W, Fani Negar, Flinkenflügel Kira, Friedman Naomi P, Gotlib Ian H, Groenewold Nynke A, Grotegerd Dominik, Hajek Tomas, Hatoum Alexander S, Hermesdorf Marco, Hickie Ian B, Hirano Yoshiyuki, Ho Tiffany C, Ikemizu Yuki, Iorfino Frank, Ipser Jonathan C, Isobe Yuko, Jackowski Andrea P, Jollant Fabrice, Kircher Tilo, Klug Melissa, Koopowitz Sheri-Michelle, Kraus Anna, Krug Axel, Le Bars Emmanuelle, Leehr Elisabeth J, Li Meng, Lippard Elizabeth T C, Lopez-Jaramillo Carlos, Maximov Ivan I, McIntosh Andrew M, McLaughlin Katie A, McWhinney Sean R, Meinert Susanne, Melloni Elisa, Mitchell Philip B, Mwangi Benson, Nenadić Igor, Nerland Stener, Olie Emilie, Ortiz-García de la Foz Victor, Pan Pedro M, Pereira Fabricio, Piras Fabrizio, Piras Federica, Poletti Sara, Reineberg Andrew E, Roberts Gloria, Romero-García Rafael, Sacchet Matthew D, Salum Giovanni A, Sandu Anca-Larisa, Sellgren Carl M, Shimizu Eiji, Smolker Harry R, Soares Jair C, Spalletta Gianfranco, Douglas Steele J, Stein Frederike, Stein Dan J, Straube Benjamin, Teutenberg Lea, Thomas-Odenthal Florian, Usemann Paula, Valabregue Romain, Valencia-Echeverry Johanna, Wagner Gerd, Waiter Gordon, Walter Martin, Whalley Heather C, Wu Mon-Ju, Yang Tony T, Zarate Carlos A, Zugman Andre, Zunta-Soares Giovana B, van Heeringen Kees, van Rooij Sanne J H, van der Wee Nic, van der Werff Steven, Thompson Paul M, Blumberg Hilary P, van Harmelen Anne-Laura, Rentería Miguel E, Jahanshad Neda, Schmaal Lianne
Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
medRxiv. 2024 Nov 7:2024.11.07.24316876. doi: 10.1101/2024.11.07.24316876.
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (=652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls; =1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls; =642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation (=714; mean age=36.3±15.3; female=66.1%), clinical controls (=1184; mean age=36.8±15.6; female=63.1%), and healthy controls (=1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen's < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.
先前的研究表明，白质（WM）微观结构的改变与自杀念头和行为（STB）有关。然而，扩散张量成像（DTI）研究的结果并不一致。在由ENIGMA自杀念头和行为（ENIGMA-STB）联盟进行的这项大规模荟萃分析中，我们研究了与STB相关的WM改变。各研究地点的数据处理进行了标准化，来自40个队列的25条WM束的WM微观结构测量结果（分数各向异性、轴向扩散率、平均扩散率和径向扩散率）进行了汇总。我们比较了有精神疾病诊断且有自杀未遂终生史的个体（=652；平均年龄=35.4±14.7；女性=71.8%）、有精神疾病诊断但无STB的个体（即临床对照；=1871；平均年龄=34±14.8；女性=59.8%）以及无精神疾病诊断且无STB的个体（即健康对照；=642；平均年龄=29.6±13.1；女性=62.9%）之间的这些测量结果。我们还比较了近期有自杀意念的个体（=714；平均年龄=36.3±15.3；女性=66.1%）、临床对照（=1184；平均年龄=36.8±15.6；女性=63.1%）和健康对照（=1240；平均年龄=31.6±15.5；女性=61.0%）之间的这些测量结果。我们发现了细微但具有统计学意义的影响，例如与自杀未遂史相关的分数各向异性较低，这超出了精神疾病诊断的影响。这些影响在放射冠、丘脑辐射、穹窿/终纹、胼胝体和上纵束中最为明显。效应大小较小（科恩效应量<0.25）。近期的自杀意念与WM微观结构的改变无关。这项大规模的协同荟萃分析揭示了有自杀未遂史的个体在WM微观结构上存在细微的区域和整体改变。需要进行纵向研究来确认这些改变是否是自杀行为的危险因素。
