Raaphorst G P, Azzam E I
Int J Radiat Oncol Biol Phys. 1985 Apr;11(4):855-9. doi: 10.1016/0360-3016(85)90321-9.
Two homozygous and heterozygous ataxia telangiectasia (AT) cell strains were compared to normal human cells for heat and radiation responses. The thermal sensitivities to one hour heating at 42.0 degrees C were comparable in the five cell strains. Thermal enhancement of radiosensitivity occurred in both homo- and hetero-zygous AT cell strains and was comparable to the thermal enhancement observed in the normal cell strain. Normal cells recovered during incubation at 37.0 degrees C between the two treatments of heat and X rays while homozygous AT cells showed no recovery. The heterozygous cell strains showed only a slight sequence dependence for heat and radiation sensitivity.
将两个纯合和杂合的共济失调毛细血管扩张症（AT）细胞株与正常人类细胞进行热和辐射反应的比较。在这五种细胞株中，对42.0摄氏度下一小时加热的热敏感性相当。纯合和杂合AT细胞株均出现放射敏感性的热增强，且与正常细胞株中观察到的热增强相当。正常细胞在热和X射线两种处理之间于37.0摄氏度孵育期间恢复，而纯合AT细胞未显示恢复。杂合细胞株对热和辐射敏感性仅表现出轻微的序列依赖性。
