Jung Sungmin, Bufton Jack, Bao Zeqing, Cho Wonjoon, Aguiar Dean, Allen Christine
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.
Pendant Inc, JLabs Toronto, 661 University Avenue, Suite 1300, Toronto M5G 0B7, Canada.
Data Brief. 2024 Dec 4;58:111182. doi: 10.1016/j.dib.2024.111182. eCollection 2025 Feb.
Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection. A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide--glycolide) [1]. To expand the range of polymers available for use, cross-linkable allyl functionalized, polyester copolymers were considered for preparation of disc-shaped, implantable delivery systems for TAF. The physico-chemical properties of the implants were evaluated including thermal and spectral properties as well as stability. Subsequently the discs were loaded with TAF via a swelling-equilibrium approach and the discs were further characterized including, TAF loading and drug release. This dataset shows the potential of using these polymeric materials as a sustained delivery platform for TAF. The dataset is freely available on Mendeley Data.
替诺福韦艾拉酚胺（TAF）目前通过口服给药用于治疗慢性乙型肝炎病毒感染，并作为人类免疫缺陷病毒（HIV）感染联合治疗方案的一部分。作为该药物的一种制剂策略，长效给药系统具有诸多优势，包括提高患者依从性、便利性、药物水平更稳定以及潜在的副作用更少。迄今为止，绝大多数基于聚合物的长效给药系统都是由聚（丙交酯-乙交酯）制备的[1]。为了扩大可用聚合物的范围，考虑使用可交联的烯丙基官能化聚酯共聚物来制备用于TAF的盘状可植入给药系统。对植入物的物理化学性质进行了评估，包括热性质、光谱性质以及稳定性。随后通过溶胀平衡法将TAF载入盘中，并对盘进行进一步表征，包括TAF载药量和药物释放情况。该数据集展示了使用这些聚合物材料作为TAF持续给药平台的潜力。该数据集可在Mendeley Data上免费获取。
