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临床认可的可生物降解长效注射剂：行业视角

Clinically established biodegradable long acting injectables: An industry perspective.

作者信息

Nkanga Christian Isalomboto, Fisch Andreas, Rad-Malekshahi Mazda, Romic Marieta Duvnjak, Kittel Birgit, Ullrich Thomas, Wang Jing, Krause Rui Werner Maçedo, Adler Sabine, Lammers Twan, Hennink Wim E, Ramazani Farshad

机构信息

Center for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa; Faculty of Pharmaceutical Sciences, University of Kinshasa, B.P. 212, Kinshasa, XI, Democratic Republic of the Congo; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland.

Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland.

出版信息

Adv Drug Deliv Rev. 2020 Dec;167:19-46. doi: 10.1016/j.addr.2020.11.008. Epub 2020 Nov 14.

DOI:10.1016/j.addr.2020.11.008
PMID:33202261
Abstract

Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.

摘要

长效注射制剂已被开发出来，以在所需时间段内维持药物在体内的作用。这些给药平台已用于全身和局部药物递送应用。本综述概述了目前正在临床使用的长效注射系统。这些产品分为三类：可生物降解的聚合物系统，包括微粒和植入物；微纳晶体悬浮液和油基制剂。此外，还总结了这些药物递送平台在各种慢性病管理中的应用。最后，本综述探讨了长效注射制剂开发方面的行业挑战。

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Clinically established biodegradable long acting injectables: An industry perspective.

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[3]
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[4]
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[5]
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[6]
Development of a Melting Point Depression Method to Measure the Solubility of a Small-Molecule Drug in Poly-Lactic-co-Glycolic Acid (PLGA).

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[7]
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Sci Data. 2025-3-1

[8]
GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy.

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[9]
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[10]
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