Sahu Saroj K, Nath Preetam, Mallick Bipadabhanjan, Praharaj Dibyalochan, Giri Suprabhat, Panigrahi Sarat C, Anand Anil C
Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.
Euroasian J Hepatogastroenterol. 2024 Jul-Dec;14(2):187-190. doi: 10.5005/jp-journals-10018-1448. Epub 2024 Dec 27.
Obstructive jaundice (OJ) and acute cholangitis (AC) are common presentations of biliary obstruction. In Eastern India, data regarding the causes of OJ and AC are scarce. This study aimed to determine the etiological spectrum of OJ and AC in a tertiary center in Eastern India.
The data of consecutive patients admitted to the Department of Gastroenterology from January 2021 to December 2023 with a diagnosis of OJ with or without AC was collected from the hospital's computerized database. The data were analyzed for different etiologies of OJ and AC. The results were compared with the various etiologies of OJ reported in previous publications from different centers across India.
Totally 772 patients were admitted during this period with a diagnosis of OJ with or without AC. There were 368 male and 404 female patients with a male-to-female ratio of 0.91. In 454 (58.8%) and 309 (41.2%) cases, the etiology of OJ was benign biliary obstruction (BBO) and malignant biliary obstruction (MBO), respectively. The etiologies of BBO-associated OJ were choledocholithiasis (51%) and distal biliary stricture (9%). The causes of MBO-associated OJ were gallbladder cancer (GBC) (21%), periampullary malignancy (10.2%), cholangiocarcinoma (CCA) (5.3%), and carcinoma head of the pancreas (3.4%). Acute cholangitis was observed in 203 (26.2%) with OJ; 23% and 10% of cases of BBO-associated OJ and MBO-associated OJ had AC, respectively. BBOs that presented with AC were choledocholithiasis (50.24%) and distal biliary stricture (14.77%). Similarly, MBOs that presented with AC were GBC (16.74%), periampullary malignancy (10.34%), CCA (6.4%), and carcinoma head of the pancreas (0.0098%).
Among the etiologies of AC and OJ, BBOs were more common than MBOs. The most common cause of OJ was choledocholithiasis. Gallbladder cancer was the second most common cause of OJ and the most common cause of malignancy-associated OJ. The most common benign and malignant etiologies of AC were choledocholithiasis and GBC, respectively.
Sahu SK, Nath P, Mallick B, Etiological Profile of Obstructive Jaundice and Acute Cholangitis: Three-year Data from a Tertiary Care Center in Eastern India. Euroasian J Hepato-Gastroenterol 2024;14(2):187-190.
梗阻性黄疸（OJ）和急性胆管炎（AC）是胆道梗阻的常见表现。在印度东部，关于OJ和AC病因的数据较为匮乏。本研究旨在确定印度东部一家三级中心OJ和AC的病因谱。
收集2021年1月至2023年12月连续入住胃肠病科且诊断为伴或不伴AC的OJ患者的数据，这些数据来自医院的计算机数据库。对OJ和AC的不同病因进行分析。将结果与印度不同中心先前发表的关于OJ的各种病因进行比较。
在此期间，共有772例患者被诊断为伴或不伴AC的OJ。其中男性368例，女性404例，男女比例为0.91。在454例（58.8%）和309例（41.2%）病例中，OJ的病因分别为良性胆道梗阻（BBO）和恶性胆道梗阻（MBO）。BBO相关OJ的病因是胆总管结石（51%）和远端胆管狭窄（9%）。MBO相关OJ的病因是胆囊癌（GBC）（21%）、壶腹周围恶性肿瘤（10.2%）、胆管癌（CCA）（5.3%）和胰头癌（3.4%）。203例（26.2%）OJ患者出现急性胆管炎；BBO相关OJ和MBO相关OJ病例中分别有23%和10%出现AC。出现AC的BBO病因是胆总管结石（50.24%）和远端胆管狭窄（14.77%）。同样，出现AC的MBO病因是GBC（16.74%）、壶腹周围恶性肿瘤（10.34%）、CCA（6.4%）和胰头癌（0.0098%）。
在AC和OJ的病因中，BBO比MBO更常见。OJ最常见的病因是胆总管结石。胆囊癌是OJ的第二大常见病因，也是恶性肿瘤相关OJ的最常见病因。AC最常见的良性和恶性病因分别是胆总管结石和GBC。
Sahu SK, Nath P, Mallick B, 梗阻性黄疸和急性胆管炎的病因概况：来自印度东部一家三级医疗中心的三年数据。《欧亚肝脏胃肠病学杂志》2024；14(2):187 - 190。
