Agarwal Reshu, Gupta Ekta, Samal Jasmine, Rooge Sheetalnath, Gupta Akshita
Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India.
Euroasian J Hepatogastroenterol. 2024 Jul-Dec;14(2):214-220. doi: 10.5005/jp-journals-10018-1450. Epub 2024 Dec 27.
Chronic Hepatitis B (CHB) remains a major public health problem, leading to various complications such as liver fibrosis, cirrhosis, and hepatocellular carcinoma. The existing diagnostic markers for Hepatitis B virus (HBV) are limited in distinguishing different CHB phases and intra-hepatic viral replication activity. In the past few years, several non-invasive potential blood markers that reflect viral intra-hepatic replicative state more accurately have been in progress and are gaining importance. Despite substantial efforts, the clinical utility of these new markers in CHB management is limited and unexplored. Therefore, in this review, we will discuss some of the newer HBV markers, their potential role in the diagnosis and monitoring of CHB patients.
Agarwal R, Gupta E, Samal J, Newer Diagnostic Virological Markers for Hepatitis B Virus Infection. Euroasian J Hepato-Gastroenterol 2024;14(2):214-220.
慢性乙型肝炎(CHB)仍然是一个重大的公共卫生问题,会导致各种并发症,如肝纤维化、肝硬化和肝细胞癌。现有的乙型肝炎病毒(HBV)诊断标志物在区分不同的CHB阶段和肝内病毒复制活性方面存在局限性。在过去几年中,几种能够更准确反映病毒肝内复制状态的非侵入性潜在血液标志物正在研究中,且越来越受到重视。尽管付出了巨大努力,但这些新标志物在CHB管理中的临床应用仍然有限且尚未得到充分探索。因此,在本综述中,我们将讨论一些较新的HBV标志物,及其在CHB患者诊断和监测中的潜在作用。
Agarwal R, Gupta E, Samal J, 用于乙型肝炎病毒感染的新型诊断病毒学标志物。《欧亚肝脏胃肠病学杂志》2024年;14(2):214 - 220。