Duhamel Frederik, Unuane David, Brock Stefanie, Cosyns Stefan, Balti Eric
Endocrine and Diabetes Unit, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, BEL.
Department of Internal Medicine, Vrije Universiteit Brussel (VUB), Brussels, BEL.
Cureus. 2024 Dec 13;16(12):e75640. doi: 10.7759/cureus.75640. eCollection 2024 Dec.
Hyperandrogenism is a highly prevalent and debilitating hormonal disturbance encountered in women presenting with variable phenotypical features. Causes encompass a large spectrum of tumoral and nontumoral etiologies, depending on the patients' age. We report two postmenopausal patients with an unusual etiology of hyperandrogenism. Both underwent salpingo-oophorectomy. While the first patient was cured after bilateral salpingo-oophorectomy, the second patient had residual disease after unilateral surgical management. Complete disease control was achieved after the adjunction of medical treatment. This report emphasizes the indication of bilateral salpingo-oophorectomy for the management of hyperandrogenism in postmenopausal women. A better understanding of the added value of presurgical hormonal status in further characterization of the disease phenotype is needed.
高雄激素血症是一种在具有不同表型特征的女性中高度普遍且使人衰弱的激素紊乱。其病因包括多种肿瘤性和非肿瘤性病因，具体取决于患者年龄。我们报告了两名绝经后高雄激素血症病因不寻常的患者。两人均接受了输卵管卵巢切除术。第一名患者在双侧输卵管卵巢切除术后治愈，而第二名患者在单侧手术治疗后仍有残留疾病。在辅助药物治疗后实现了疾病的完全控制。本报告强调了双侧输卵管卵巢切除术在绝经后女性高雄激素血症管理中的适应证。需要更好地理解术前激素状态在进一步明确疾病表型方面的附加价值。
