Shiromani Sakshi, Pattathil Niveditha, Sadeghi Elham, Choudhry Netan, Chhablani Jay
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Vitreous Retina Macula Specialists of Toronto, Toronto, ON, Canada.
Taiwan J Ophthalmol. 2024 Dec 20;14(4):510-518. doi: 10.4103/tjo.TJO-D-24-00125. eCollection 2024 Oct-Dec.
Wide field retinal imaging has emerged as a transformative technology over the last few decades, revolutionizing our ability to visualize the intricate landscape of the retina. By capturing expansive retinal areas, these techniques offer a panoramic view going beyond traditional imaging methods. In this review, we explore the significance of retinal imaging-based biomarkers to help diagnose ocular and systemic conditions. We discuss quantitative biomarkers, including ischemic index, nonperfusion area and more, and their application in diabetic retinopathy, central retinal vein occlusion, neurodegenerative diseases, and more. In addition, we outline qualitative biomarkers such as choroidal venous hyperpermeability and intervortex anastomoses. The role of wide field fundus autofluorescence in assessing hereditary retinal diseases is also emphasized. Standardized imaging procedures, professional collaboration, and validation across a range of clinical circumstances are necessary for the effective use of these biomarkers. They have the potential to transform disease identification, risk assessment, and customize therapy.
在过去几十年中，广角视网膜成像已成为一项变革性技术，彻底改变了我们可视化视网膜复杂结构的能力。通过捕获广阔的视网膜区域，这些技术提供了超越传统成像方法的全景视图。在本综述中，我们探讨基于视网膜成像的生物标志物对眼部和全身疾病诊断的重要性。我们讨论了定量生物标志物，包括缺血指数、无灌注区等，以及它们在糖尿病性视网膜病变、视网膜中央静脉阻塞、神经退行性疾病等中的应用。此外，我们概述了定性生物标志物，如脉络膜静脉高渗透性和涡静脉间吻合。还强调了广角眼底自发荧光在评估遗传性视网膜疾病中的作用。有效使用这些生物标志物需要标准化的成像程序、专业合作以及在一系列临床情况下的验证。它们有可能改变疾病识别、风险评估和定制治疗。
