肺移植受者中坚毅与心理韧性与移植后短期结局的关联
Association of Grit and Resilience With Short-Term Post-Transplant Outcomes in Lung Allograft Recipients.
作者信息
Dragnich Alexander G, Chapin Kaitlyn C, Xu Ke, Liu Jinyuan, Lipworth Loren, Shaver Ciara M, Trindade Anil J
机构信息
Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt Transplant Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
出版信息
Clin Transplant. 2025 Jan;39(1):e70082. doi: 10.1111/ctr.70082.
The importance of mental toughness on lung transplant outcomes is unknown. We performed a pilot study to assess whether pretransplant grit and resilience are associated with short-term posttransplant outcomes. We enrolled 31 lung transplant candidates, of whom 7 (26%) had greater mental toughness, defined as the upper tertile for both grit and resilience within our cohort. There were no differences in baseline characteristics between patients with higher and lower mental toughness. Greater mental toughness was associated with a shorter hospital length of stay (LOS) [12 days (interquartile range, IQR 10-12) vs. 17 days (IQR 14-24), p = 0.02] and reduced posttraumatic stress severity [median 0 (IQR 0-2) vs. 6.5 (IQR 4-9), p < 0.01]. On multivariable analyses adjusting for age and Duke Activity Status Index, greater mental toughness was associated with a shorter hospital LOS [beta = -11.96 (95% CI 0.05-23.86), p < 0.05] and reduced PTSD [beta = -10.7 (95% CI -21.6-0.04), p = 0.053]. Lung transplant candidates with greater mental toughness may have improved short-term outcomes.
心理韧性对肺移植结果的重要性尚不清楚。我们进行了一项试点研究，以评估移植前的毅力和恢复力是否与移植后的短期结果相关。我们招募了31名肺移植候选人，其中7人（26%）具有更强的心理韧性，即在我们的队列中毅力和恢复力均处于上三分位数。心理韧性较高和较低的患者在基线特征上没有差异。更强的心理韧性与更短的住院时间（LOS）相关[12天（四分位间距，IQR 10 - 12）对17天（IQR 14 - 24），p = 0.02]以及创伤后应激严重程度降低相关[中位数0（IQR 0 - 2）对6.5（IQR 4 - 9），p < 0.01]。在对年龄和杜克活动状态指数进行调整的多变量分析中，更强的心理韧性与更短的住院LOS相关[β = -11.96（95% CI 0.05 - 23.86），p < 0.05]以及创伤后应激障碍（PTSD）减轻相关[β = -10.7（95% CI -21.6 - 0.04），p = 0.053]。心理韧性更强的肺移植候选人可能有更好的短期结果。
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