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丹麦、芬兰、挪威和瑞典儿童哮喘的趋势。

Trends in childhood asthma in Denmark, Finland, Norway and Sweden.

作者信息

Gehrt Lise, Vahlkvist Signe, Petersen Thomas Houmann, Englund Hélène, Nieminen Heta, Laake Ida, Kofoed Poul-Erik, Feiring Berit, Benn Christine Stabell, Trogstad Lill, Sørup Signe

机构信息

Bandim Health Project, Research Unit OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark.

出版信息

Acta Paediatr. 2025 Jun;114(6):1329-1337. doi: 10.1111/apa.17573. Epub 2025 Jan 13.

Abstract

AIM

Estimate the incidence of asthma among children aged 0 to 15 years in Denmark, Finland, Norway and Sweden during 2000-2017.

METHODS

Cases of preschool asthma (up to 6 years) and school-age asthma (from 6 years) were identified through national registers using an algorithm including hospital diagnoses and prescription medicines. The respective cumulative incidence (CI) was estimated in 1-year age intervals for each country and birth year.

RESULTS

The CI of algorithm-based preschool asthma peaked for the birth cohorts 2008 or 2009 at 14.8% in Denmark, 11.0% in Finland, 15.1% in Norway and 13.7% in Sweden. For later birth cohorts, a slight decrease was observed. The CI of school-age asthma was 7.1% in Denmark, 10.5% in Finland, 9.7% in Norway and 10.2% in Sweden (children born in 2002). A slight decline over time was seen in Denmark and Norway, and a slight increase in Sweden and Finland.

CONCLUSION

Finland had a markedly lower CI of preschool asthma and Denmark lower CI of school-age asthma as estimated by prescriptions and hospital diagnoses. Preschool asthma may have plateaued in the Nordic countries. For school-age asthma trends over time varied by country. Differences in diagnostic and prescription practices may have influenced the results.

摘要

目的

估算2000年至2017年丹麦、芬兰、挪威和瑞典0至15岁儿童哮喘的发病率。

方法

通过国家登记册,利用包括医院诊断和处方药在内的算法,确定学龄前哮喘(6岁及以下)和学龄期哮喘(6岁及以上)病例。分别按每个国家和出生年份的1岁年龄间隔估算累积发病率(CI)。

结果

基于算法的学龄前哮喘累积发病率在丹麦2008年或2009年出生队列中达到峰值,为14.8%;在芬兰为11.0%;在挪威为15.1%;在瑞典为13.7%。对于较晚出生的队列,观察到略有下降。学龄期哮喘的累积发病率在丹麦为7.1%,在芬兰为10.5%,在挪威为9.7%,在瑞典为10.2%(2002年出生的儿童)。丹麦和挪威随时间略有下降,瑞典和芬兰略有上升。

结论

根据处方和医院诊断估算,芬兰学龄前哮喘的累积发病率明显较低,丹麦学龄期哮喘的累积发病率较低。北欧国家学龄前哮喘发病率可能已趋于平稳。学龄期哮喘发病率随时间的趋势因国家而异。诊断和处方做法的差异可能影响了结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f7a/12066901/25f1e76947a8/APA-114-1329-g001.jpg

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