Lesar T S, Tollefson G, Koch M
J Clin Psychiatry. 1985 Apr;46(4):133-6.
The relationships between several patient variables and lithium dosage requirements were determined in 71 inpatients receiving a slow-release lithium product. Age, weight, ideal body weight, sex, body surface area, creatinine clearance, presence of depression, concurrent use of tricyclic antidepressants, and acuteness of symptoms were significantly related to dosage requirements. The contribution of each factor to dosage requirements was further defined using multiple regression analysis and used to assess a published patient variable-based lithium dosing technique. Addition to that model of information concerning presence of depression, acuteness of symptoms, and creatinine clearance minimally improved predictability. The published model is recommended as an alternative to empiric methods.
在71名接受缓释锂产品治疗的住院患者中，确定了几个患者变量与锂剂量需求之间的关系。年龄、体重、理想体重、性别、体表面积、肌酐清除率、是否存在抑郁、是否同时使用三环类抗抑郁药以及症状的急性程度与剂量需求显著相关。使用多元回归分析进一步确定了每个因素对剂量需求的影响，并用于评估一种已发表的基于患者变量的锂剂量计算技术。将有关抑郁状态、症状急性程度和肌酐清除率的信息添加到该模型中，对预测能力的改善微乎其微。建议将已发表的模型作为经验方法的替代方法。
