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Tranexamic acid in hip fracture repair surgery: safe and effective?

作者信息

Lasocki Sigismond, Campfort Maëva, Léger Maxime, Rineau Emmanuel

机构信息

Département Anesthésie Réanimation, CHU Angers, Université d'Angers, Angers, France.

出版信息

Blood Transfus. 2025 Jan;23(1):83-86. doi: 10.2450/BloodTransfus.933. Epub 2025 Jan 13.

DOI:10.2450/BloodTransfus.933
PMID:39804756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11841949/
Abstract
摘要

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Tranexamic acid in hip fracture repair surgery: safe and effective?氨甲环酸在髋部骨折修复手术中的应用：安全有效吗？
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Tranexamic acid in hip fracture surgery: a randomized controlled trial.氨甲环酸在髋部骨折手术中的应用：一项随机对照试验。
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Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews.成人髋部骨折手术中减少红细胞输血的干预措施：系统评价概述。
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Injury. 2021 Aug;52(8):2361-2366. doi: 10.1016/j.injury.2021.01.032. Epub 2021 Feb 2.
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Is intravenous tranexamic acid effective and safe during hip fracture surgery? An updated meta-analysis of randomized controlled trials.静脉注射氨甲环酸在髋部骨折手术中是否有效且安全？一项随机对照试验的更新荟萃分析。
Arch Orthop Trauma Surg. 2019 Jul;139(7):893-902. doi: 10.1007/s00402-019-03118-6. Epub 2019 Jan 14.
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Tranexamic acid in  hip fracture surgery: A systematic review and meta-analysis of efficacy and safety.氨甲环酸在髋部骨折手术中的应用：疗效与安全性的系统评价和荟萃分析
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Intravenous tranexamic acid and thromboembolic events in hip fracture surgery: A systematic review and meta-analysis.静脉注射氨甲环酸与髋部骨折手术中的血栓栓塞事件：一项系统评价与荟萃分析。
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Does perioperative use of tranexamic acid in hip fracture patients increase the risk of venous thromboembolism and reduce the need for postoperative transfusions?髋部骨折患者围手术期使用氨甲环酸是否会增加静脉血栓栓塞的风险并减少术后输血需求？
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Is there no such thing as a free lunch? With Patient Blood Management, maybe there is!天下没有免费的午餐？对于患者血液管理而言，或许有！
Blood Transfus. 2025 Jan;23(1):1-4. doi: 10.2450/BloodTransfus.1024.

本文引用的文献

1
Perioperative Patient Blood Management (excluding obstetrics): Guidelines from the French National Authority for Health.围手术期患者血液管理（不包括产科）：法国国家卫生管理局指南。
Anaesth Crit Care Pain Med. 2024 Oct;43(5):101404. doi: 10.1016/j.accpm.2024.101404. Epub 2024 Jul 9.
2
A randomised controlled trial assessing the effect of tranexamic acid on post-operative blood transfusions in patient with intra-capsular hip fractures treated with hemi- or total hip arthroplasty.一项随机对照试验，评估氨甲环酸对接受半髋关节置换术或全髋关节置换术治疗的囊内髋部骨折患者术后输血的影响。
Arch Orthop Trauma Surg. 2024 Jul;144(7):3095-3102. doi: 10.1007/s00402-024-05325-2. Epub 2024 Jun 7.
3
Variation in care and outcome for fragile hip fracture patients: a European multicentre study benchmarking fulfilment of established quality indicators.
脆性髋部骨折患者的护理和结局存在差异：一项对既定质量指标达成情况进行基准测试的欧洲多中心研究。
Eur J Trauma Emerg Surg. 2024 Oct;50(5):2421-2430. doi: 10.1007/s00068-024-02549-0. Epub 2024 May 31.
4
Reduction of red blood cell transfusion with a patient blood management protocol in urological and visceral surgery: a before-after study.采用患者血液管理方案减少泌尿外科和内脏外科的红细胞输血：一项前后对照研究。
Anaesth Crit Care Pain Med. 2024 Aug;43(4):101395. doi: 10.1016/j.accpm.2024.101395. Epub 2024 May 23.
5
Efficacy and Safety of Orally and Intravenously Administration of Tranexamic Acid in Patients with Elderly Femoral Neck Fracture.口服和静脉给予氨甲环酸治疗老年股骨颈骨折患者的疗效和安全性。
Orthop Surg. 2024 Jul;16(7):1581-1591. doi: 10.1111/os.14089. Epub 2024 May 20.
6
Intravenous Versus Locally Injected Tranexamic Acid in a Fragility Hip Fracture Population: A Retrospective Review.静脉注射与局部注射氨甲环酸在脆性髋部骨折人群中的应用：一项回顾性研究。
J Orthop Trauma. 2024 Mar 1;38(3):e79-e84. doi: 10.1097/BOT.0000000000002737.
7
Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial.去铁胺麦芽糖铁和氨甲环酸，联合或单独用药，用于减少髋部骨折患者的输血（HiFIT 试验）：一项多中心、2×2 析因、随机、双盲、对照试验。
Lancet Haematol. 2023 Sep;10(9):e747-e755. doi: 10.1016/S2352-3026(23)00163-1. Epub 2023 Jul 28.
8
Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews.成人髋部骨折手术中减少红细胞输血的干预措施：系统评价概述。
Cochrane Database Syst Rev. 2023 Jun 8;6(6):CD013737. doi: 10.1002/14651858.CD013737.pub2.
9
Efficacy and safety of tranexamic acid for patients with intertrochanteric fractures treated with intramedullary fixation: A systematic review and meta-analysis of current evidence in randomized controlled trials.氨甲环酸用于髓内固定治疗的粗隆间骨折患者的疗效和安全性：一项对随机对照试验现有证据的系统评价和荟萃分析
Front Pharmacol. 2022 Sep 19;13:945971. doi: 10.3389/fphar.2022.945971. eCollection 2022.
10
Update on the efficacy and safety of intravenous tranexamic acid in hip fracture surgery: a systematic review and meta-analysis.静脉用氨甲环酸在髋部骨折手术中的疗效和安全性的最新进展：系统评价和荟萃分析。
Eur J Orthop Surg Traumatol. 2023 Jul;33(5):2179-2190. doi: 10.1007/s00590-022-03387-9. Epub 2022 Sep 26.