Zhu Ling-Na, Xiang Dong-Lin, Zuo Jiang-Cheng, Wang Guang-Yong, Xiao Ning
From the Yiling People's Hospital of Yichang City, Yichang, Hubei, China.
J Occup Environ Med. 2025 Feb 1;67(2):79-82. doi: 10.1097/JOM.0000000000003263. Epub 2024 Nov 15.
This study evaluates the utility of serum s-αKlotho levels as a quantifiable biomarker for overwork.
Frontline medical workers aged 20-55 years from Yiling People's Hospital of Yichang were recruited. Criteria included nonsmokers, non-heavy drinkers, no chronic medication use, and no acute illnesses recently. Participants worked over 10 hours per day, 60 hours weekly, and had at least 3 years of experience. A control group was matched except for work conditions. Data were collected through surveys, and serum levels were measured.
Significant differences in serum Klotho were found between overwork and control groups. The overwork group had higher median s-αKlotho levels (49.99 pg/mL) compared to controls (27.88 pg/mL).
Overworked medical workers exhibited elevated serum s-αKlotho, suggesting s-αKlotho as a potential biomarker for overwork. Future research should use multicenter designs with larger samples to validate findings.
本研究评估血清s-αKlotho水平作为过度劳累的可量化生物标志物的效用。
招募了宜昌夷陵人民医院年龄在20至55岁的一线医务工作者。标准包括不吸烟、不酗酒、近期无慢性药物使用且无急性疾病。参与者每天工作超过10小时，每周工作60小时，且至少有3年工作经验。除工作条件外，对照组进行匹配。通过调查收集数据，并测量血清水平。
过度劳累组和对照组之间血清Klotho存在显著差异。与对照组（27.88 pg/mL）相比，过度劳累组的s-αKlotho水平中位数更高（49.99 pg/mL）。
过度劳累的医务工作者血清s-αKlotho升高，提示s-αKlotho作为过度劳累的潜在生物标志物。未来的研究应采用多中心设计和更大样本量来验证研究结果。
