Osteoarticular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Geriatric Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
PLoS One. 2024 Nov 18;19(11):e0312562. doi: 10.1371/journal.pone.0312562. eCollection 2024.
Osteoarthritis (OA) is a degenerative joint disease prevalent in the elderly. Currently, the relationship between the senescence inhibitor Klotho and OA remains unclear. This study investigated the relationship between serum soluble Klotho (S-Klotho) and OA.
This cross-sectional study was based on the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Three multifactorial logistic regression models were constructed to assess the association between serum Klotho and OA. Restricted cubic spline (RCS) curves were further used to assess whether there was a nonlinear relationship between serum Klotho and OA. Finally, stratified analyses and interaction tests were used to evaluate the association's stability. To further investigate the relationship between serum Klotho and OA, we recruited 107 patients for analysis at the First Affiliated Hospital of Guangxi Medical University.
The final 8,918 participants included in this study comprised 50.55% females and 49.45% males, with 18.10% of participants suffering from OA and a mean S-Klotho level of 846.41 (5.61) pg/ml. All three logistic regression models observed a negative association between continuous S-Klotho and OA risk. When S-Klotho was categorized into tertiles, the fully adjusted model showed that participants in the third tertile had a 17% lower risk of OA than those in the first tertile (OR = 0.83, 95% CI: 0.70, 0.99, P = 0.035). The RCS curves showed a linear negative association between S-Klotho and the incidence of OA (P for overall = 0.025; P for non-linearity = 0.667). Further subgroup analyses and interaction tests suggested that the negative association between S-Klotho and OA remained stable in different conditions. Research conducted in China has shown that the negative correlation between serum Klotho levels and the prevalence of OA remains evident among Chinese individuals (OR: 0.77, 95% CI: 0.66, 0.90, P<0.001).
Our study suggests that elevated levels of the senescence inhibitor S-Klotho may be a potential protective factor for OA, which may provide new insights into the diagnosis and treatment of OA.
骨关节炎（OA）是一种常见于老年人的退行性关节疾病。目前，衰老抑制剂 Klotho 与 OA 之间的关系尚不清楚。本研究探讨了血清可溶性 Klotho（S-Klotho）与 OA 之间的关系。
本横断面研究基于 2007-2016 年全国健康与营养调查（NHANES）。构建了三个多因素逻辑回归模型来评估血清 Klotho 与 OA 之间的关联。进一步使用限制立方样条（RCS）曲线来评估血清 Klotho 与 OA 之间是否存在非线性关系。最后，进行分层分析和交互检验以评估关联的稳定性。为了进一步研究血清 Klotho 与 OA 之间的关系，我们在广西医科大学第一附属医院招募了 107 名患者进行分析。
本研究最终纳入 8918 名参与者，其中 50.55%为女性，49.45%为男性，18.10%的参与者患有 OA，血清 S-Klotho 水平的平均值为 846.41（5.61）pg/ml。所有三个逻辑回归模型均观察到连续 S-Klotho 与 OA 风险之间呈负相关。当 S-Klotho 分为三分位时，完全调整后的模型显示，第三分位组参与者患 OA 的风险比第一分位组低 17%（OR=0.83，95%CI：0.70，0.99，P=0.035）。RCS 曲线显示 S-Klotho 与 OA 发生率之间呈线性负相关（整体 P=0.025；非线性 P=0.667）。进一步的亚组分析和交互检验表明，S-Klotho 与 OA 之间的负相关在不同条件下保持稳定。在中国开展的研究表明，血清 Klotho 水平与 OA 患病率之间的负相关在中国人群中仍然存在（OR：0.77，95%CI：0.66，0.90，P<0.001）。
本研究表明，衰老抑制剂 S-Klotho 水平升高可能是 OA 的潜在保护因素，这可能为 OA 的诊断和治疗提供新的思路。
