Park Jae-Min, Choi Ja-Eun, Lee Ji-Won, Hong Kyung-Won
Department of Family Medicine, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Republic of Korea.
Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Republic of Korea.
Lifestyle Genom. 2025;18(1):20-26. doi: 10.1159/000543543. Epub 2025 Jan 13.
Smoking cessation is influenced by genetic and environmental factors, particularly genetic polymorphisms influencing nicotine metabolism. This study investigated the association between specific nicotine metabolism-related genetic variants and smoking cessation among Korean men.
A candidate gene association study was performed targeting single nucleotide polymorphisms (SNPs) within nicotine metabolism-related genes. Participants were categorized as never, former, or current smokers. A Genetic Risk Score (GRS) was computed using significant SNPs to evaluate cumulative genetic influence.
Six SNPs showed significant association with smoking cessation in a Korean cohort. A higher GRS was associated with increased odds of current smoking compared to former smoking (OR = 1.18, 95% CI: 1.12-1.25, p < 0.001).
This study indicates a substantial genetic component in smoking cessation, highlighting the importance of population-specific approaches, and may aid personalized smoking cessation strategies based on genetic predisposition among Koreans.
戒烟受遗传和环境因素影响，尤其是影响尼古丁代谢的基因多态性。本研究调查了韩国男性中特定尼古丁代谢相关基因变异与戒烟之间的关联。
针对尼古丁代谢相关基因内的单核苷酸多态性（SNP）进行了候选基因关联研究。参与者被分为从不吸烟者、曾经吸烟者或当前吸烟者。使用显著的SNP计算遗传风险评分（GRS）以评估累积遗传影响。
在韩国队列中，六个SNP与戒烟显示出显著关联。与曾经吸烟相比，较高的GRS与当前吸烟几率增加相关（OR = 1.18，95% CI：1.12 - 1.25，p < 0.001）。
本研究表明戒烟中存在大量遗传成分，突出了针对特定人群方法的重要性，并可能有助于基于韩国人遗传易感性的个性化戒烟策略。
