Smith Payton L, Bruffett Phoebe, Zengin Sena, Guram Mavinder, Zoumberos Nicholas A, Patel Vijay M, Evans Megan S
University of Arkansas for Medical Sciences College of Medicine, Little Rock, Arkansas, USA.
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Pediatr Dermatol. 2025 Jul-Aug;42(4):822-825. doi: 10.1111/pde.15873. Epub 2025 Jan 13.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of non-Hodgkin lymphoma characterized by subcutaneous nodules, indurated plaques, erythema, and cellular infiltrates in the subcutaneous fat. Biopsies show neoplastic cells expressing cytotoxic T-cell markers and displaying moderate cytologic atypia while sparing the dermis and epidermis and showing variable degrees of necrosis, hemorrhage, and inflammatory changes. We describe a pediatric case of SPTCL in a 6-year-old boy, presenting with an unusual targetoid plaque and systemic symptoms, who showed significant improvement on systemic immunosuppressants without chemotherapy. This case underscores the potential for atypical presentations of SPTCL and the efficacy of immunosuppressive therapy in achieving favorable clinical outcomes, adding to the understanding of SPTCL's clinical diversity and treatment strategies.
皮下脂膜炎样T细胞淋巴瘤（SPTCL）是一种罕见的非霍奇金淋巴瘤，其特征为皮下结节、硬结性斑块、红斑以及皮下脂肪中的细胞浸润。活检显示肿瘤细胞表达细胞毒性T细胞标志物，呈现中度细胞异型性，同时不累及真皮和表皮，并表现出不同程度的坏死、出血和炎症变化。我们描述了一名6岁男孩患SPTCL的儿科病例，该患儿表现为不寻常的靶样斑块和全身症状，在未进行化疗的情况下接受全身免疫抑制剂治疗后有显著改善。该病例强调了SPTCL非典型表现的可能性以及免疫抑制治疗在实现良好临床结局方面的有效性，增进了对SPTCL临床多样性和治疗策略的理解。
