确定用于治疗髓系恶性肿瘤的供体淋巴细胞输注的谱系特异性嵌合阈值。 - Suppr

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超能文献

Defining a lineage-specific chimerism threshold for the use of donor lymphocyte infusions in treating myeloid malignancies.

作者信息

Puzo Christian J, Seropian Stuart, Rinder Henry, Tormey Christopher A, Siddon Alexa J

机构信息

Yale School of Medicine, New Haven, CT, USA.

Department of Hematology, Yale School of Medicine, New Haven, CT, USA.

出版信息

Bone Marrow Transplant. 2025 Apr;60(4):535-537. doi: 10.1038/s41409-025-02510-8. Epub 2025 Jan 13.

DOI:10.1038/s41409-025-02510-8

PMID:39806028

Abstract

摘要

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Defining a lineage-specific chimerism threshold for the use of donor lymphocyte infusions in treating myeloid malignancies.确定用于治疗髓系恶性肿瘤的供体淋巴细胞输注的谱系特异性嵌合阈值。

Bone Marrow Transplant. 2025 Apr;60(4):535-537. doi: 10.1038/s41409-025-02510-8. Epub 2025 Jan 13.

Navigating preemptive and therapeutic donor lymphocyte infusions in advanced myeloid malignancies by high-sensitivity chimerism analysis.通过高灵敏度嵌合分析指导晚期髓系恶性肿瘤的抢先性和治疗性供体淋巴细胞输注

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Predominant or complete recipient T-cell chimerism following alemtuzumab-based allogeneic transplantation is reversed by donor lymphocytes and not associated with graft failure.在基于阿仑单抗的异基因移植后，主要或完全的受者 T 细胞嵌合被供者淋巴细胞逆转，且与移植物衰竭无关。

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本文引用的文献

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.成人 AML 的诊断与治疗：ELN 专家组代表发布的 2022 年国际专家建议

Blood. 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867.

Utility of assessing CD3 cell chimerism within the first months after allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia.异基因造血干细胞移植后最初几个月内评估 CD3 细胞嵌合体在急性髓系白血病中的应用。

HLA. 2022 Jul;100(1):18-23. doi: 10.1111/tan.14557. Epub 2022 Jan 30.

The Elephant in The Room: AML Relapse Post Allogeneic Hematopoietic Cell Transplantation.显而易见的问题：异基因造血细胞移植后急性髓系白血病复发

Front Oncol. 2022 Jan 3;11:793274. doi: 10.3389/fonc.2021.793274. eCollection 2021.

Performance Status Assessment by Using ECOG (Eastern Cooperative Oncology Group) Score for Cancer Patients by Oncology Healthcare Professionals.肿瘤医疗专业人员使用东部肿瘤协作组（ECOG）评分对癌症患者进行的体能状态评估。

Case Rep Oncol. 2019 Sep 25;12(3):728-736. doi: 10.1159/000503095. eCollection 2019 Sep-Dec.

Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.急性髓系白血病和骨髓增生异常综合征的清髓性与减低强度造血细胞移植

J Clin Oncol. 2017 Apr 10;35(11):1154-1161. doi: 10.1200/JCO.2016.70.7091. Epub 2017 Feb 13.

Mixed T Lymphocyte Chimerism after Allogeneic Hematopoietic Transplantation Is Predictive for Relapse of Acute Myeloid Leukemia and Myelodysplastic Syndromes.异基因造血移植后的混合性T淋巴细胞嵌合现象可预测急性髓系白血病和骨髓增生异常综合征的复发。

Biol Blood Marrow Transplant. 2015 Nov;21(11):1948-54. doi: 10.1016/j.bbmt.2015.07.005. Epub 2015 Jul 14.

Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival.减低强度预处理造血干细胞移植后早期供体嵌合现象可预测复发和生存。

Biol Blood Marrow Transplant. 2014 Oct;20(10):1516-21. doi: 10.1016/j.bbmt.2014.05.025. Epub 2014 Jun 4.

Monitoring of acute myeloid leukemia patients after allogeneic stem cell transplantation employing semi-automated CD34+ donor cell chimerism analysis.采用半自动 CD34+供体细胞嵌合分析监测异基因造血干细胞移植后的急性髓系白血病患者。

Ann Hematol. 2014 Feb;93(2):279-85. doi: 10.1007/s00277-013-1961-4. Epub 2013 Dec 19.

Impact of T cell chimerism on clinical outcome in 117 patients who underwent allogeneic stem cell transplantation with a busulfan-containing reduced-intensity conditioning regimen.117例接受含白消安的减低强度预处理方案的异基因干细胞移植患者中T细胞嵌合状态对临床结局的影响。

Biol Blood Marrow Transplant. 2008 Oct;14(10):1148-1155. doi: 10.1016/j.bbmt.2008.07.013.

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.急性髓系白血病治疗试验的诊断、反应标准标准化、治疗结果及报告标准国际工作组修订建议

J Clin Oncol. 2003 Dec 15;21(24):4642-9. doi: 10.1200/JCO.2003.04.036.

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