Mohammadkhanloo Mahdi, Pooyan Mohammad, Sharini Hamid, Yousefpour Mitra
Department of Biomedical Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran.
Department of Biomedical Engineering, Shahed University, Tehran, Iran.
BMC Med Imaging. 2025 Jan 13;25(1):18. doi: 10.1186/s12880-024-01527-7.
Cognitive networks impairments are common in neuropsychiatric disorders like Attention Deficit Hyperactivity Disorder (ADHD), bipolar disorder (BD), and schizophrenia (SZ). While previous research has focused on specific brain regions, the role of the procedural memory as a type of long-term memory to examine cognitive networks impairments in these disorders remains unclear. This study investigates alterations in resting-state functional connectivity (rs-FC) within the procedural memory network to explore brain function associated with cognitive networks in patients with these disorders.
This study analyzed resting-state functional magnetic resonance imaging (rs-fMRI) data from 40 individuals with ADHD, 49 with BD, 50 with SZ, and 50 healthy controls (HCs). A procedural memory network was defined based on the selection of 34 regions of interest (ROIs) associated with the network in the Harvard-Oxford Cortical Structural Atlas (default atlas). Multivariate region of interest to region of interest connectivity (mRRC) was used to analyze the rs-FC between the defined network regions. Significant differences in rs-FC between patients and HCs were identified (P < 0.001).
ADHD patients showed increased Cereb45 l - Cereb3 r rs-FC (p = 0.000067) and decreased Cereb1 l - Cereb6 l rs-FC (p = 0.00092). BD patients exhibited increased rs-FC between multiple regions, including Claustrum r - Caudate r (p = 0.00058), subthalamic nucleus r - Pallidum l (p = 0.00060), substantia nigra l - Cereb2 l (p = 0.00082), Cereb10 r - SMA r (p = 0.00086), and Cereb9 r - SMA l (p = 0.00093) as well as decreased rs-FC in subthalamic nucleus r - Cereb6 l (p = 0.00013) and Cereb9 r - Cereb9 l (p = 0.00033). SZ patients indicated increased Caudate r- putamen l rs-FC (p = 0.00057) and decreased rs-FC in subthalamic nucleus r - Cereb6 l (p = 0.000063), and Cereb1 r - subthalamic nucleus r (p = 0.00063).
This study found significant alterations in rs-FC within the procedural memory network in patients with ADHD, BD, and SZ compared to HCs. These findings suggest that disrupted rs-FC within this network may related to cognitive networks impairments observed in these disorders.
Not applicable.
认知网络损伤在注意力缺陷多动障碍（ADHD）、双相情感障碍（BD）和精神分裂症（SZ）等神经精神疾病中很常见。虽然先前的研究集中在特定脑区，但程序记忆作为一种长期记忆在检查这些疾病中的认知网络损伤方面的作用仍不清楚。本研究调查程序记忆网络内静息态功能连接（rs-FC）的改变，以探索这些疾病患者中与认知网络相关的脑功能。
本研究分析了40名ADHD患者、49名BD患者、50名SZ患者和50名健康对照（HCs）的静息态功能磁共振成像（rs-fMRI）数据。基于在哈佛-牛津皮质结构图谱（默认图谱）中与该网络相关的34个感兴趣区域（ROIs）的选择来定义程序记忆网络。使用多变量感兴趣区域到感兴趣区域连接（mRRC）来分析定义的网络区域之间的rs-FC。确定了患者与HCs之间rs-FC的显著差异（P < 0.001）。
ADHD患者显示Cereb45 l - Cereb3 r的rs-FC增加（p = 0.000067），Cereb1 l - Cereb6 l的rs-FC减少（p = 0.00092）。BD患者在多个区域之间表现出rs-FC增加，包括右侧屏状核 - 右侧尾状核（p = 0.00058）、右侧丘脑底核 - 左侧苍白球（p = 0.00060）、左侧黑质 - 左侧Cereb2（p = 0.00082）、右侧Cereb10 - 右侧辅助运动区（p = 0.00086）和右侧Cereb9 - 左侧辅助运动区（p = 0.00093），以及右侧丘脑底核 - 左侧Cereb6（p = 0.00013）和右侧Cereb9 - 左侧Cereb9（p = 0.00033）的rs-FC减少。SZ患者显示右侧尾状核 - 左侧壳核的rs-FC增加（p = 0.00057），右侧丘脑底核 - 左侧Cereb6（p = 0.000063）和右侧Cereb1 - 右侧丘脑底核（p = 0.00063）的rs-FC减少。
本研究发现，与HCs相比，ADHD、BD和SZ患者的程序记忆网络内rs-FC有显著改变。这些发现表明，该网络内rs-FC的破坏可能与这些疾病中观察到的认知网络损伤有关。
不适用。
