Ma Yaoyao, Lv Wenting, Guo Yi, Yin Tong, Bai Yujie, Liu Ziqi, Chen Chao, Feng Jiayi, Qian Wenbin, Tang Ruiling, Su Yanting, Shan Shigang, Dong Huifen, Bao Yongfen, Qu Lihua
Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and Technology, Hubei, 437000, China.
School of Basic Medical Sciences, Hubei University of Science and Technology, Hubei, 437000, China.
Cell Commun Signal. 2025 Jan 13;23(1):24. doi: 10.1186/s12964-024-02006-w.
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses. Among post-translational modifications, histone lysine methylation holds significant importance. There are over 30 members of histone lysine demethylases (KDMs), which act as epigenetic regulators in physiological processes and diseases. Importantly, KDMs are abnormally expressed in the regulation of cellular autophagy and inflammation, representing a crucial mechanism affecting inflammation-related diseases. This article reviewed the function of KDMs proteins in autophagy and inflammation. Specifically, It focused on the specific regulatory mechanisms underlying the activation or inhibition of autophagy, as well as their abnormal expression in inflammatory responses. By analyzing each KDM in epigenetic modification, this review provides a reliable theoretical basis for clinical decision marking regarding autophagy abnormalities and inflammatory diseases.
自噬功能障碍与自噬相关基因的变化有关。多种因素与自噬相关，且调节自噬的机制非常复杂。表观遗传变化，如组蛋白去甲基化酶的异常表达，不仅与肿瘤发生密切相关，还与炎症反应有关。在翻译后修饰中，组蛋白赖氨酸甲基化具有重要意义。组蛋白赖氨酸去甲基化酶（KDMs）有30多个成员，它们在生理过程和疾病中作为表观遗传调节因子发挥作用。重要的是，KDMs在细胞自噬和炎症调节中异常表达，是影响炎症相关疾病的关键机制。本文综述了KDMs蛋白在自噬和炎症中的作用。具体而言，重点关注了自噬激活或抑制的具体调控机制，以及它们在炎症反应中的异常表达。通过分析表观遗传修饰中的每种KDM，本综述为自噬异常和炎症性疾病的临床决策提供了可靠的理论依据。
