a Department of Biology , Federico II University , Naples , Italy.
b Telethon Institute of Genetics and Medicine (TIGEM) , Pozzuoli, Naples , Italy.
Autophagy. 2019 Feb;15(2):187-196. doi: 10.1080/15548627.2018.1520546. Epub 2018 Sep 22.
Macroautophagy/autophagy is a physiological mechanism that is essential for the maintenance of cellular homeostasis and stress adaptation. Defective autophagy is associated with many human diseases, including cancer and neurodegenerative disorders. The emerging implication of epigenetic events in the control of the autophagic process opens new avenues of investigation and offers the opportunity to develop novel therapeutic strategies in diseases associated with dysfunctional autophagy-lysosomal pathways. Accumulating evidence reveals that several methyltransferases and demethylases are essential regulators of autophagy, and recent studies have led to the identification of the lysine demethylase KDM1A/LSD1 as a promising drug target. KDM1A/LSD1 modulates autophagy at multiple levels, participating in the transcriptional control of several downstream effectors. This review summarizes our current understanding of the role of KDM1A/LSD1 in the autophagy regulatory network.
自噬是一种生理机制，对于维持细胞内环境平衡和应激适应至关重要。自噬功能缺陷与许多人类疾病有关，包括癌症和神经退行性疾病。越来越多的证据表明，表观遗传事件在自噬过程的调控中起着重要作用，这为开发与自噬-溶酶体途径功能障碍相关疾病的新型治疗策略提供了新的研究途径。积累的证据表明，几种甲基转移酶和去甲基酶是自噬的重要调节剂，最近的研究导致了赖氨酸去甲基酶 KDM1A/LSD1 作为一个有前途的药物靶点的鉴定。KDM1A/LSD1 通过参与几个下游效应物的转录控制，在多个水平上调节自噬。这篇综述总结了我们目前对 KDM1A/LSD1 在自噬调节网络中的作用的理解。
