Glaviano Antonino, Lau Hannah Si-Hui, Carter Lukas M, Lee E Hui Clarissa, Lam Hiu Yan, Okina Elena, Tan Donavan Jia Jie, Tan Wency, Ang Hui Li, Carbone Daniela, Yee Michelle Yi-Hui, Shanmugam Muthu K, Huang Xiao Zi, Sethi Gautam, Tan Tuan Zea, Lim Lina H K, Huang Ruby Yun-Ju, Ungefroren Hendrik, Giovannetti Elisa, Tang Dean G, Bruno Tullia C, Luo Peng, Andersen Mads Hald, Qian Bin-Zhi, Ishihara Jun, Radisky Derek C, Elias Salem, Yadav Saurabh, Kim Minah, Robert Caroline, Diana Patrizia, Schalper Kurt A, Shi Tao, Merghoub Taha, Krebs Simone, Kusumbe Anjali P, Davids Matthew S, Brown Jennifer R, Kumar Alan Prem
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy.
Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.
J Hematol Oncol. 2025 Jan 13;18(1):6. doi: 10.1186/s13045-024-01634-6.
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and invasiveness and promote metastasis and cancer progression. By targeting various components of the TME, novel investigational strategies aim to disrupt the TME's contribution to the EMT, thereby improving treatment efficacy, addressing therapeutic resistance, and offering a nuanced approach to cancer therapy. This review scrutinizes the key players in the TME and the TME's contribution to the EMT, emphasizing avenues to therapeutically disrupt the interactions between the various TME components. Moreover, the article discusses the TME's implications for resistance mechanisms and highlights the current therapeutic strategies toward TME modulation along with potential caveats.
肿瘤微环境（TME）是癌症进展不可或缺的一部分，影响着转移和治疗反应。它由多种细胞类型、细胞外基质成分和信号分子组成，这些成分相互作用以促进肿瘤生长和治疗抗性。阐明癌细胞与TME之间复杂的相互作用对于理解癌症进展和治疗挑战至关重要。TME信号传导诱导的一个关键过程是上皮-间质转化（EMT），其中上皮细胞获得间质特征，这增强了它们的运动性和侵袭性，并促进转移和癌症进展。通过靶向TME的各种成分，新的研究策略旨在破坏TME对EMT的作用，从而提高治疗效果，解决治疗抗性问题，并为癌症治疗提供一种细致入微的方法。这篇综述审视了TME中的关键参与者以及TME对EMT的作用，强调了从治疗上破坏各种TME成分之间相互作用的途径。此外，本文讨论了TME对耐药机制的影响，并强调了当前针对TME调节的治疗策略以及潜在的注意事项。
