Li Xiaobing, Wang Xuezhu, Chen Guifang, Tian Bo
Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Biomater Sci. 2025 Feb 11;13(4):896-912. doi: 10.1039/d4bm01450b.
Reactive oxygen species (ROS) play essential roles in both physiological and pathological processes. Under physiological conditions, appropriate amounts of ROS play an important role in signaling and regulation in cells. However, too much ROS can lead to many health problems, including inflammation, cancer, delayed wound healing, neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease), and autoimmune diseases, and oxidative stress from excess ROS is also one of the most critical factors in the pathogenesis of cardiovascular and metabolic diseases such as atherosclerosis. Hydrogen gas effectively removes ROS from the body due to its good antioxidant properties, and hydrogen therapy has become a promising gas therapy strategy due to its inherent safety and stability. The combination of nanomaterials can achieve targeted delivery and effective accumulation of hydrogen, and has some ameliorating effects on diseases. Herein, we summarize the use of hydrogen-producing nanomaterials for the treatment of ROS-related diseases and talk about the prospects for the treatment of other ROS-induced disease models, such as acute kidney injury.
活性氧（ROS）在生理和病理过程中都起着至关重要的作用。在生理条件下，适量的ROS在细胞信号传导和调节中发挥重要作用。然而，过多的ROS会导致许多健康问题，包括炎症、癌症、伤口愈合延迟、神经退行性疾病（如帕金森病和阿尔茨海默病）以及自身免疫性疾病，并且过量ROS引起的氧化应激也是动脉粥样硬化等心血管和代谢疾病发病机制中最关键的因素之一。氢气因其良好的抗氧化性能可有效清除体内的ROS，并且由于其固有的安全性和稳定性，氢疗法已成为一种有前景的气体治疗策略。纳米材料的组合可以实现氢气的靶向递送和有效积累，并对疾病具有一定的改善作用。在此，我们总结了产氢纳米材料在治疗ROS相关疾病中的应用，并探讨了其在治疗其他ROS诱导的疾病模型（如急性肾损伤）方面的前景。
