Liu YanBin, Zuo LiJuan, Xin YunChao, Liu YaChao, Tian ZeDong, Shang XiaoLing
The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
J Invest Surg. 2025 Dec;38(1):2447850. doi: 10.1080/08941939.2024.2447850. Epub 2025 Jan 14.
Extant imaging methods used for the proper identification of the parathyroid glands to prevent post-operative hypothyroidism associated with the resection of differentiated thyroid cancer (DTC) are limited by factors such as low specificity, high cost, and technical complexity. This study, therefore, sought to investigate the efficacy of the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during radical resection of DTC in elderly patients.
A total of 100 elderly patients with DTC were enrolled and randomly divided into two groups: the control group and the observation group. The control group underwent conventional radical thyroidectomy with bilateral cervical lymph node dissection, while the observation group received the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during the surgery. The baseline characteristics, intraoperative findings, postoperative parathyroid hormone (PTH), and serum calcium levels, as well as postoperative complications, were compared between the two groups.
There were no significant differences in age, gender, body mass index, comorbidities, or smoking history between the two groups. The observation group had a significantly higher number of parathyroid glands identified during surgery compared with the control group. The postoperative PTH and serum calcium levels at postoperative days 1 and 3 and at 6 months were significantly higher in the observation group than those in the control group. The incidence of postoperative hypoparathyroidism was significantly lower in the observation group.
The immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology is effective in identifying and preserving parathyroid glands during radical resection of DTC in elderly patients.
用于准确识别甲状旁腺以预防分化型甲状腺癌（DTC）切除术后甲状腺功能减退的现有成像方法受到诸如特异性低、成本高和技术复杂性等因素的限制。因此，本研究旨在探讨免疫胶体金试纸法联合纳米碳负性成像示踪技术在老年患者DTC根治性切除术中对甲状旁腺成像的有效性。
共纳入100例老年DTC患者，随机分为两组：对照组和观察组。对照组行常规甲状腺癌根治术并双侧颈淋巴结清扫，而观察组在手术期间采用免疫胶体金试纸法联合纳米碳负性成像示踪技术对甲状旁腺进行成像。比较两组患者的基线特征、术中发现、术后甲状旁腺激素（PTH）和血清钙水平以及术后并发症。
两组患者在年龄、性别、体重指数、合并症或吸烟史方面无显著差异。与对照组相比，观察组在手术中识别出的甲状旁腺数量明显更多。观察组术后第1天、第3天和6个月时的术后PTH和血清钙水平明显高于对照组。观察组术后甲状旁腺功能减退的发生率明显更低。
免疫胶体金试纸法联合纳米碳负性成像示踪技术在老年患者DTC根治性切除术中对甲状旁腺的识别和保留有效。
