Belete Yegzeru, Kuma Abera, Habtamu Wasyihun, Fulas Munewer, Girma Abdulkerim, Tadesse Sinetibeb, Anegagregn Amanuel
School of Medicine, College of Medicine and Health Sciences Hawassa University Hawassa Ethiopia.
Neurology Unit, Department of Internal Medicine, College of Medicine and Health Sciences Hawassa University Hawassa Ethiopia.
Clin Case Rep. 2025 Jan 12;13(1):e70095. doi: 10.1002/ccr3.70095. eCollection 2025 Jan.
This case series highlights the diverse presentations of seropositive neuromyelitis optica spectrum disorder, including the absence of optic neuritis despite anti-aquaporin 4 antibody positivity. It emphasizes the importance of high index of suspicion, early neurologist referral for improved outcomes, the consequences of delayed referral, and the challenges and treatment potential in low-income countries with limited resources.
本病例系列突出了血清学阳性视神经脊髓炎谱系障碍的多种表现,包括尽管抗水通道蛋白4抗体呈阳性但无视神经炎的情况。它强调了高度怀疑的重要性、早期转诊给神经科医生以改善预后、延迟转诊的后果,以及资源有限的低收入国家所面临的挑战和治疗潜力。