Gibson Jess T, Barr Hudson J, Boe Shaun G
Laboratory for Brain Recovery and Function, Dalhousie University, Halifax, NS, CAN.
PhD Health Program, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, CAN.
Int J Exerc Sci. 2024 Dec 1;17(2):1429-1443. doi: 10.70252/QMEY1068. eCollection 2024.
Aerobic exercise has been shown to impact corticospinal excitability (CSE), however the mechanism(s) by which this occurs is unclear. Some evidence suggests an increase in blood lactate concentration resulting from exercise may be what is driving these changes in corticospinal excitability. The extent of literature examining this effect and whether it is consistent across the literature is unknown. As such, the objective of this scoping review was to summarize the existing literature examining the effect of lactate on corticospinal excitability and to determine any trend(s) in the effect. Embase, CINAHL, Medline, SPORTDiscus, and PsycInfo were systematically searched to retrieve original research reporting on blood lactate concentration and measures of corticospinal excitability associated with aerobic or high intensity interval exercise. Two reviewers independently determined study eligibility, and one reviewer extracted data from all eligible studies. The database search yielded 717 papers of which 9 were determined eligible. Multiple studies in which participants completed high intensity and/or exhaustive exercise showed a correlation between large increases in blood lactate concentration and increased corticospinal excitability, however several other studies noted no difference in corticospinal excitability following an increase in blood lactate concentration. This review showed that the existing body of literature is small and highly variable in both methods and results, therefore we can draw limited conclusions about the role of lactate, however based on the evidence available lactate does not appear to be the key player in the modulation of CSE. In addition, evidence from other literature supports moderate intensity aerobic exercise as a modulator of neuroplasticity, suggesting that there may be other key factors contributing to the changes in the brain following exercise.
有氧运动已被证明会影响皮质脊髓兴奋性（CSE），然而其发生机制尚不清楚。一些证据表明，运动导致的血乳酸浓度升高可能是驱动皮质脊髓兴奋性发生这些变化的原因。研究这种效应的文献数量以及该效应在文献中是否一致尚不清楚。因此，本范围综述的目的是总结现有研究乳酸对皮质脊髓兴奋性影响的文献，并确定该效应的任何趋势。我们系统检索了Embase、CINAHL、Medline、SPORTDiscus和PsycInfo数据库，以获取关于血乳酸浓度以及与有氧运动或高强度间歇运动相关的皮质脊髓兴奋性测量的原始研究报告。两名评审员独立确定研究的合格性，一名评审员从所有合格研究中提取数据。数据库检索共得到717篇论文，其中9篇被确定为合格。多项参与者完成高强度和/或力竭运动的研究表明，血乳酸浓度大幅升高与皮质脊髓兴奋性增加之间存在相关性，然而其他一些研究指出，血乳酸浓度升高后皮质脊髓兴奋性并无差异。本综述表明，现有文献数量较少，且在方法和结果上高度可变，因此我们对乳酸作用的结论有限，不过根据现有证据，乳酸似乎不是调节CSE的关键因素。此外，其他文献的证据支持中等强度有氧运动作为神经可塑性的调节因素，这表明运动后大脑变化可能还有其他关键因素。
