Nepveu Jean-Francois, Thiel Alexander, Tang Ada, Fung Joyce, Lundbye-Jensen Jesper, Boyd Lara A, Roig Marc
1 Memory and Motor Rehabilitation Laboratory (MEMORY-LAB).
3 Montreal Center for Interdisciplinary Research in Rehabilitation (CRIR), Montreal, Quebec, Canada.
Neurorehabil Neural Repair. 2017 Aug;31(8):726-735. doi: 10.1177/1545968317718269. Epub 2017 Jul 8.
One bout of high-intensity cardiovascular exercise performed immediately after practicing a motor skill promotes changes in the neuroplasticity of the motor cortex and facilitates motor learning in nondisabled individuals.
To determine if a bout of exercise performed at high intensity is sufficient to induce neuroplastic changes and improve motor skill retention in patients with chronic stroke.
Twenty-two patients with different levels of motor impairment were recruited. On the first session, the effects of a maximal graded exercise test on corticospinal and intracortical excitability were assessed from the affected and unaffected primary motor cortex representational area of a hand muscle with transcranial magnetic stimulation. On the second session, participants were randomly assigned to an exercise or a nonexercise control group. Immediately after practicing a motor task, the exercise group performed 15 minutes of high-intensity interval training while the control group rested. Twenty-four hours after motor practice all participants completed a test of the motor task to assess skill retention.
The graded exercise test reduced interhemispheric imbalances in GABA-mediated short-interval intracortical inhibition but changes in other markers of excitability were not statistically significant. The group that performed high-intensity interval training showed a better retention of the motor skill.
The performance of a maximal graded exercise test triggers only modest neuroplastic changes in patients with chronic stroke. However, a single bout of high-intensity interval training performed immediately after motor practice improves skill retention, which could potentially accelerate motor recovery in these individuals.
在练习一项运动技能后立即进行一轮高强度心血管运动，可促进运动皮层神经可塑性的变化，并有助于非残疾个体的运动学习。
确定一轮高强度运动是否足以在慢性中风患者中诱发神经可塑性变化并改善运动技能保持能力。
招募了22名具有不同运动障碍水平的患者。在第一阶段，通过经颅磁刺激从手部肌肉的患侧和未患侧初级运动皮层代表区评估最大分级运动测试对皮质脊髓和皮质内兴奋性的影响。在第二阶段，参与者被随机分配到运动组或非运动对照组。在练习一项运动任务后，运动组立即进行15分钟的高强度间歇训练，而对照组休息。运动练习24小时后，所有参与者完成运动任务测试以评估技能保持情况。
分级运动测试减少了GABA介导的短间隔皮质内抑制的半球间不平衡，但其他兴奋性标志物的变化无统计学意义。进行高强度间歇训练的组表现出更好的运动技能保持能力。
最大分级运动测试仅在慢性中风患者中引发适度的神经可塑性变化。然而，在运动练习后立即进行一轮高强度间歇训练可改善技能保持能力，这可能会加速这些个体的运动恢复。
