评估血液学参数作为家族性地中海热成年患者亚临床炎症标志物的研究

Evaluation of Hematological Parameters as Markers for Subclinical Inflammation in Adults with Familial Mediterranean Fever.

作者信息

Abd Rabou Mohamed Gamal, Ramadan Ali Mahmoud, Mohsen Ahmed Mohamed, Shawky Marwa

机构信息

Department of Tropical Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

出版信息

Middle East J Dig Dis. 2024 Oct;16(4):242-249. doi: 10.34172/mejdd.2024.399. Epub 2024 Oct 30.

DOI:10.34172/mejdd.2024.399

PMID:39807412

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11725023/

Abstract

BACKGROUND

Repeated polyserositis, another name for familial Mediterranean fever (FMF), is an autoimmune disorder with an autosomal recessive nature primarily characterized by short-lived repeated periods of peritonitis, pleuritis, and arthritis, generally accompanied by fever.

METHODS

Our participants were divided into two groups. Group I (patients): 100 individuals who were diagnosed as patients with FMF and were monitored. Group II (control): matched- healthy individuals (100 controls). They were compared and followed up as regards demographic, clinical, and laboratory data: routine investigations, neutrophil/lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV), red cell distribution width (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).

RESULTS

Group I: MPV mean was 12.03±2.89, whereas group II MPV mean was 7.74±0.57. MPV was significantly statistically greater in group I than in group II. RDW mean in group I was 17.07±1.39 and in group II was 12.92±0.63. RDW was also significantly statistically greater in group I compared with group II. Group I's NLR mean was 3.05±0.71, whereas group II's NLR mean was 1.75±0.2. PLR mean in group I was 164.8±122.8 and in group II was 111.26±29.16.

CONCLUSION

A statistically significant association was shown between the diagnosis of adult FMF and NLR, PLR, MPV, and RDW.

摘要

背景

复发性多浆膜炎，即家族性地中海热（FMF）的别称，是一种常染色体隐性自身免疫性疾病，主要特征为短暂反复发作的腹膜炎、胸膜炎和关节炎，通常伴有发热。

方法

我们的参与者被分为两组。第一组（患者组）：100名被诊断为FMF的患者并接受监测。第二组（对照组）：匹配的健康个体（100名对照）。对他们的人口统计学、临床和实验室数据进行比较和随访：常规检查、中性粒细胞/淋巴细胞比值（NLR）、血小板淋巴细胞比值（PLR）、平均血小板体积（MPV）、红细胞分布宽度（RDW）、C反应蛋白（CRP）和红细胞沉降率（ESR）。

结果

第一组：MPV平均值为12.03±2.89，而第二组MPV平均值为7.74±0.57。第一组的MPV在统计学上显著高于第二组。第一组的RDW平均值为17.07±1.39，第二组为12.92±0.63。与第二组相比，第一组的RDW在统计学上也显著更高。第一组的NLR平均值为3.05±0.71，而第二组的NLR平均值为1.75±0.2。第一组的PLR平均值为164.8±122.8，第二组为111.26±29.16。