美国成年人中新型炎症标志物与血清25-羟基维生素D之间的关系。

The Relationship Between Novel Inflammatory Markers and Serum 25-Hydroxyvitamin D Among US Adults.

作者信息

Zhao Hang, Zhao Yangyang, Fang Yini, Zhou Weibang, Zhang Wenjing, Peng Jiecheng

机构信息

Department of Cardiology, Anqing First People's Hospital of Anhui Medical University, Anqing, China.

The Fifth Clinical College of Anhui Medical University, Hefei, China.

出版信息

Immun Inflamm Dis. 2025 Jan;13(1):e70115. doi: 10.1002/iid3.70115.

DOI:10.1002/iid3.70115

PMID:39807747

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729997/

Abstract

BACKGROUND

Vitamin D is the focus of extensive medical research globally. Recent studies have investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and common inflammatory markers. However, few studies have incorporated novel inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), platelet-to-high density lipoprotein cholesterol ratio (PHR), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response (SIRI), and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR). This study investigated these correlations among adults in the USA.

METHODS

We ultimately included a total of 5308 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007 to 2018. A multivariable linear regression model assessed the links between serum 25(OH)D and these novel inflammatory markers, with subgroup analyses for hypertension and diabetes. To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. Upon detecting nonlinear relationships, we used a recursive algorithm to pinpoint the inflection point.

RESULTS

In our multivariate linear regression model, serum 25(OH)D concentrations were negatively correlated with NHR (β = -0.003, 95% CI: -0.005 to -0.001), NLR (β = -0.002, 95% CI: -0.003 to 0.000), SII (β = -0.579, 95% CI: -0.954 to -0.205), PHR (β = -0.171, 95% CI: -0.249 to -0.093), and PLR (β = -0.096, 95% CI: -0.051 to -0.040) among adults in the USA. Nevertheless, no significant association was found with SIRI (β = -0.001, 95% CI: -0.002 to 0.000). Subgroup analysis by hypertension and diabetes showed that in the hypertensive group, serum 25(OH)D was significantly and negatively associated with NHR, NLR, SII, SIRI, PHR, and PLR. However, no correlation was found in the diabetic group between serum 25(OH)D levels and these inflammatory markers.

CONCLUSIONS

Our research confirms that serum 25(OH)D levels are negatively correlated with several novel inflammatory markers among adults in the USA, suggesting potential directions for further research into vitamin D's role in inflammation.

摘要

背景

维生素D是全球广泛医学研究的焦点。最近的研究调查了血清25-羟基维生素D（25(OH)D）与常见炎症标志物之间的相关性。然而，很少有研究纳入血小板与淋巴细胞比率（PLR）、血小板与高密度脂蛋白胆固醇比率（PHR）、全身炎症指数（SII）、中性粒细胞与淋巴细胞比率（NLR）、全身炎症反应（SIRI）以及中性粒细胞与高密度脂蛋白胆固醇比率（NHR）等新型炎症标志物。本研究调查了美国成年人中这些指标之间的相关性。

方法

我们最终纳入了2007年至2018年美国国家健康与营养检查调查（NHANES）数据库中的5308名参与者。采用多变量线性回归模型评估血清25(OH)D与这些新型炎症标志物之间的联系，并对高血压和糖尿病进行亚组分析。为了进一步探究两者之间的关系，我们应用了平滑曲线拟合和广义相加模型。在检测到非线性关系后，我们使用递归算法来确定拐点。

结果

在我们的多变量线性回归模型中，美国成年人血清25(OH)D浓度与NHR（β = -0.003，95%CI：-0.005至-0.001）、NLR（β = -0.002，95%CI：-0.003至0.000）、SII（β = -0.579，95%CI：-0.954至-0.205）、PHR（β = -0.171，95%CI：-0.249至-0.093）和PLR（β = -0.096，95%CI：-0.051至-0.040）呈负相关。然而，未发现与SIRI有显著关联（β = -0.001，95%CI：-0.002至0.000）。按高血压和糖尿病进行的亚组分析表明，在高血压组中，血清25(OH)D与NHR、NLR、SII、SIRI、PHR和PLR显著负相关。然而，在糖尿病组中，未发现血清25(OH)D水平与这些炎症标志物之间存在相关性。