Aljuaid Abdulelah A
Clin Lab. 2025 Jan 1;71(1). doi: 10.7754/Clin.Lab.2024.240902.
In Saudi Arabia, cervical cancer, frequently caused by human papillomavirus (HPV) infection, is a common cancer. The usual procedures for screening and diagnosing cervical cancer include Pap smears and HPV tests, even though they have considerable drawbacks, particularly for older women (> 60 years) who have limited access to or compliance with these tests. Urinalysis is a simple, noninvasive test that has been suggested as an alternative procedure. This study aimed to investigate the change in urinalysis characteristics in cervical cancer patients in elderly females and the possible use of urinalysis as a screening or diagnostic tool for cervical cancer in older women.
This was an exploratory cross-sectional study of 190 cervical cancer patients diagnosed between January 2018 and August 2021. Based on age, the study included two groups, < 60 years and ≥ 60 years. Urinalysis characteristics, including bacterial count, blood level, protein level, and squamous epithelial cell shedding, were compared between the age groups by using the chi-squared and Kruskal-Walli tests.
The results showed a significant difference between aged females and younger females with cervical cancer at the blood level, protein level, and squamous epithelial cell shedding in the urine. The older women (≥ 60 years) had higher incidences of increased bacterial count, blood levels, protein levels, and squamous epithelial cell shedding than the younger women (< 60 years).
The main finding of the study implies that there are significant changes in urine characteristics in cervical cancer patients including hyperproteinemia, hematuria, and squamous cell shedding in elderly patients compared to younger patients, and it proposes a potential role for urinalysis as a screening tool for cervical cancer in older women. Urinalysis could be a potential screening tool for cervical cancer in older women who have not been screened or have no screening access. Further studies are needed to validate these findings.
在沙特阿拉伯，宫颈癌是一种常见癌症，常由人乳头瘤病毒（HPV）感染引起。宫颈癌筛查和诊断的常规程序包括巴氏涂片和HPV检测，尽管它们有相当大的缺点，特别是对于那些难以获得或难以配合这些检测的老年女性（>60岁）。尿液分析是一种简单、无创的检测方法，已被建议作为替代程序。本研究旨在调查老年女性宫颈癌患者尿液分析特征的变化，以及尿液分析作为老年女性宫颈癌筛查或诊断工具的可能性。
这是一项对2018年1月至2021年8月期间诊断的190例宫颈癌患者进行的探索性横断面研究。根据年龄，该研究分为两组，<60岁和≥60岁。使用卡方检验和Kruskal-Wallis检验比较年龄组之间的尿液分析特征，包括细菌计数、血液水平、蛋白质水平和鳞状上皮细胞脱落情况。
结果显示，老年女性和年轻女性宫颈癌患者在血液水平、蛋白质水平和尿液中鳞状上皮细胞脱落方面存在显著差异。老年女性（≥60岁）细菌计数增加、血液水平、蛋白质水平和鳞状上皮细胞脱落的发生率高于年轻女性（<60岁）。
该研究的主要发现表明，与年轻患者相比，老年宫颈癌患者的尿液特征有显著变化，包括高蛋白血症、血尿和鳞状细胞脱落，并且提出尿液分析作为老年女性宫颈癌筛查工具的潜在作用。尿液分析可能是未接受筛查或无法进行筛查的老年女性宫颈癌的潜在筛查工具。需要进一步研究来验证这些发现。
