Lerchner T, Jedlička J, Kripnerová M, Dejmek J, Kuncová J
Institute of Physiology, Biomedical Centre, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic.
Physiol Res. 2024 Dec 31;73(S3):S685-S695. doi: 10.33549/physiolres.935500.
Mitochondria represent pivotal cellular organelles endowed with multifaceted functionalities encompassing cellular respiration, metabolic processes, calcium turnover, and the regulation of apoptosis, primarily through the generation of reactive oxygen species (ROS). Perturbations in mitochondrial dynamics have been intricately linked to the etiology of numerous cardiovascular pathologies, such as heart failure, ischemic heart disease, and various cardiomyopathies. Notably, recent attention has been directed towards the detrimental impact of micro- and nanoplastic pollution on mitochondrial integrity, an area underscored by a paucity of comprehensive investigations. Given the escalating prevalence of plastic particle contamination and the concomitant burden of cardiovascular disease in aging populations, understanding the interplay between mitochondria within the cardiovascular system and micro- and nanoplastic pollution assumes paramount importance. This review endeavors to elucidate the current albeit limited comprehension surrounding this complex interplay. Key words Mitochondria, Nanoplastics, Microplastics, Cardiovascular system, Endothelial function, Oxidative phosphorylation.
线粒体是关键的细胞器，具有多方面功能，包括细胞呼吸、代谢过程、钙周转以及细胞凋亡调控，主要通过产生活性氧（ROS）来实现。线粒体动力学的紊乱与多种心血管疾病的病因密切相关，如心力衰竭、缺血性心脏病和各种心肌病。值得注意的是，近期人们开始关注微塑料和纳米塑料污染对线粒体完整性的有害影响，而这一领域的全面研究较少。鉴于塑料颗粒污染在老年人群中的日益普遍以及心血管疾病的相应负担，了解心血管系统中线粒体与微塑料和纳米塑料污染之间的相互作用至关重要。本综述旨在阐明目前对这种复杂相互作用虽有限但的理解。关键词：线粒体、纳米塑料、微塑料、心血管系统、内皮功能、氧化磷酸化
