Ozel Aysegul, Davutoglu Ebru Alici, Firat Asuman, Erenel Hakan, Karslı Mehmet Fatih, Korkmaz Sevim Özge, Madazli Riza
a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey.
b Department of Biochemistry , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey.
J Obstet Gynaecol. 2018 Jul;38(5):642-646. doi: 10.1080/01443615.2017.1399260. Epub 2018 Feb 12.
The aim of the study was to investigate whether plasma irisin concentrations differ between uncomplicated, early-onset and late-onset pre-eclamptic pregnancies. This cross-sectional study was conducted on 27 women with early-onset, 27 women with late-onset pre-eclampsia (PE) and 26 healthy pregnant women. Maternal levels of serum irisin were measured with the use of an enzyme-linked immunosorbent assay kit. The mean maternal serum irisin level of early-onset PE was significantly lower than late-onset PE (1.14 ± 0.56 vs. 1.46 ± 0.59, p < .05) and control subjects (1.14 ± 0.56 vs. 3.14 ± 0.81, p < 0.001). The mean maternal serum irisin level of late-onset PE was significantly lower than the control group (1.46 ± 0.59 vs. 3.14 ± 0.81, p < 0.001). Maternal serum irisin levels are decreased in pre-eclamptic pregnancies. Low levels of irisin may be the result or the cause of pathologic changes in PE. Impact statement What is already known on this subject? There are only two studies in the literature evaluating maternal serum irisin levels in pre-eclamptic pregnancies. One study demonstrated decreased maternal serum irisin levels in pre-eclamptic patients and the other found no significant difference between pre-eclamptic and control pregnancies. What do the results of this study add? The present study demonstrates that serum irisin levels were significantly lower in pre-eclampsia than normotensive pregnancies. Furthermore, we have also demonstrated for the first time that women with EO-PE had significantly lower levels of serum irsin than women with LO-PE. What are the implications of these findings for clinical practice and/or further research? Low levels of irisin may be the result or the cause of pathologic changes in pre-eclampsia. More studies are needed to evaluate the relationship between irisin and pre-eclampsia.
本研究的目的是调查早发型和晚发型子痫前期未合并其他并发症的孕妇血浆鸢尾素浓度是否存在差异。本横断面研究纳入了27例早发型子痫前期孕妇、27例晚发型子痫前期（PE）孕妇和26例健康孕妇。采用酶联免疫吸附测定试剂盒检测孕妇血清鸢尾素水平。早发型PE孕妇的母体血清鸢尾素平均水平显著低于晚发型PE孕妇（1.14±0.56 vs. 1.46±0.59，p<0.05）和对照组（1.14±0.56 vs. 3.14±0.81，p<0.001）。晚发型PE孕妇的母体血清鸢尾素平均水平显著低于对照组（1.46±0.59 vs. 3.14±0.81，p<0.001）。子痫前期孕妇的母体血清鸢尾素水平降低。鸢尾素水平低可能是PE病理变化的结果或原因。影响声明关于该主题已知的信息有哪些？文献中仅有两项研究评估了子痫前期孕妇的母体血清鸢尾素水平。一项研究表明子痫前期患者的母体血清鸢尾素水平降低，另一项研究发现子痫前期孕妇与对照孕妇之间无显著差异。本研究的结果补充了什么？本研究表明，子痫前期患者的血清鸢尾素水平显著低于血压正常的孕妇。此外，我们还首次证明，早发型PE孕妇的血清鸢尾素水平显著低于晚发型PE孕妇。这些发现对临床实践和/或进一步研究有何意义？鸢尾素水平低可能是子痫前期病理变化的结果或原因。需要更多研究来评估鸢尾素与子痫前期之间的关系。
