Nicholson Wanda K, Silverstein Michael, Wong John B, Chelmow David, Coker Tumaini Rucker, Davis Esa M, Jaén Carlos Roberto, Krousel-Wood Marie, Lee Sei, Li Li, Mangione Carol M, Ogedegbe Gbenga, Rao Goutham, Ruiz John M, Stevermer James, Tsevat Joel, Underwood Sandra Millon, Wiehe Sarah
George Washington University, Washington, DC.
Brown University, Providence, Rhode Island.
JAMA. 2025 Feb 11;333(6):498-508. doi: 10.1001/jama.2024.27154.
Osteoporotic fractures are associated with psychological distress, subsequent fractures, loss of independence, reduced ability to perform activities of daily living, and death.
The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the evidence on the benefits and harms of screening for osteoporosis to prevent fractures in adults 40 years or older with no known diagnosis of osteoporosis or history of fragility fracture.
Adults 40 years or older without known osteoporosis or history of fragility fractures.
The USPSTF concludes with moderate certainty that screening for osteoporosis to prevent osteoporotic fractures in women 65 years or older has moderate net benefit. The USPSTF concludes with moderate certainty that screening for osteoporosis to prevent osteoporotic fractures in postmenopausal women younger than 65 years at increased risk has moderate net benefit. The USPSTF concludes that the evidence is insufficient and the balance of benefits and harms for screening for osteoporosis to prevent osteoporotic fractures in men cannot be determined.
The USPSTF recommends screening for osteoporosis to prevent osteoporotic fractures in women 65 years or older. (B recommendation) The USPSTF recommends screening for osteoporosis to prevent osteoporotic fractures in postmenopausal women younger than 65 years who are at increased risk for an osteoporotic fracture as estimated by clinical risk assessment. (B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for osteoporosis to prevent osteoporotic fractures in men. (I statement).
骨质疏松性骨折与心理困扰、后续骨折、失去独立生活能力、日常生活活动能力下降以及死亡相关。
美国预防服务工作组（USPSTF）委托进行了一项系统评价，以评估对40岁及以上无已知骨质疏松症诊断或脆性骨折病史的成年人进行骨质疏松症筛查以预防骨折的益处和危害的证据。
40岁及以上无已知骨质疏松症或脆性骨折病史的成年人。
USPSTF有中等把握得出结论，对65岁及以上女性进行骨质疏松症筛查以预防骨质疏松性骨折有中等净效益。USPSTF有中等把握得出结论，对65岁以下绝经后骨折风险增加的女性进行骨质疏松症筛查以预防骨质疏松性骨折有中等净效益。USPSTF得出结论，证据不足，无法确定对男性进行骨质疏松症筛查以预防骨质疏松性骨折的利弊平衡。
USPSTF建议对65岁及以上女性进行骨质疏松症筛查以预防骨质疏松性骨折。（B级推荐）USPSTF建议对65岁以下绝经后经临床风险评估估计骨质疏松性骨折风险增加的女性进行骨质疏松症筛查以预防骨质疏松性骨折。（B级推荐）USPSTF得出结论，目前的证据不足以评估对男性进行骨质疏松症筛查以预防骨质疏松性骨折的利弊平衡。（I类声明）
