Miao Zhengyang, Chen Hailin, Zhou Yongming
Department of Hematology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Medicine (Baltimore). 2024 Nov 22;103(47):e40542. doi: 10.1097/MD.0000000000040542.
The connection between Primary sclerosing cholangitis (PSC) and lymphoma remains uncertain. To address this, Mendelian randomization (MR) was utilized to investigate the potential causal links between PSC and lymphoma. A 2-sample MR analysis was conducted utilizing summary-level data obtained from genome-wide association study datasets. Four complementary MR methods were performed, including inverse-variance weighting (IVW), MR-Egger, weighted median, and MR-robust adjusted profile score (MR-RAPS). Several sensitivity analyses were also employed to further validate the results. The results of IVW estimates showed that there was a potential causal association between PSC and diffuse large B-cell lymphoma (DLBCL) risk (OR = 1.138, 95% CI = 1.052-1.230, P = .001). No causal association was observed between PSC and other lymphoma subtypes. No horizontal and directional pleiotropy was observed in the MR studies. This study represents the inaugural utilization of MR analysis to investigate the causal associations between PSC and DLBCL. Further investigation is warranted to elucidate the underlying mechanism of this causal relationship.
原发性硬化性胆管炎（PSC）与淋巴瘤之间的联系仍不明确。为解决这一问题，采用孟德尔随机化（MR）方法来研究PSC与淋巴瘤之间潜在的因果关系。利用从全基因组关联研究数据集获得的汇总水平数据进行了两样本MR分析。执行了四种互补的MR方法，包括逆方差加权（IVW）、MR-Egger、加权中位数和MR稳健调整轮廓评分（MR-RAPS）。还采用了几种敏感性分析来进一步验证结果。IVW估计结果显示，PSC与弥漫性大B细胞淋巴瘤（DLBCL）风险之间存在潜在因果关联（OR = 1.138，95%CI = 1.052 - 1.230，P = 0.001）。未观察到PSC与其他淋巴瘤亚型之间存在因果关联。在MR研究中未观察到水平和方向性多效性。本研究首次利用MR分析来研究PSC与DLBCL之间的因果关联。有必要进行进一步研究以阐明这种因果关系的潜在机制。
