Chao Linda L, Barnes Deborah E, Chesney Margaret A, Mehling Wolf E, Lee Jennifer A, Benjamin Cynthia, Lavretsky Helen, Ercoli Linda, Siddarth Prabha, Narr Katherine L
Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States of America; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, United States of America; San Francisco Veterans Affairs Health Care System, San Francisco, CA, United States of America.
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, United States of America.
Contemp Clin Trials. 2025 Feb;149:107811. doi: 10.1016/j.cct.2025.107811. Epub 2025 Jan 12.
Research suggest that mind-body movement programs have beneficial effects on cognitive outcomes for older adults with cognitive decline. However, few studies have directly compared specific approaches to mind-body movement or studied the impact of remote program delivery.
In a 3-arm randomized controlled trial (RCT) for older adults with cognitive impairment, we are comparing a multidomain mind-body program that emphasizes movement, body awareness, personal meaningfulness, and social connection, and a traditional Chinese mind-body exercise (Tai Chi) to a health and wellness education control condition. All 3 interventions are delivered remotely two times per week (onehour per session) for 12 weeks. The two active interventions are live-streamed. Outcomes are assessed prior to, after, and 6-months after the interventions. The co-primary outcomes are changes on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) and brain functional connectivity in the Default Mode Network (DMN). Secondary outcomes include measures of specific cognitive domains (e.g., executive function, attention), mobility, and self-report measures of general well-being, quality of life, social engagement, self- and attention-regulation.
This RCT will directly compare the effects of two mind-body movement programs versus an education control delivered remotely over 12 weeks on cognitive, neuroimaging, and participant-reported outcomes. If successful, these programs may provide scalable strategies for slowing cognitive decline, which could potentially delay dementia onset in some individuals.
NCT05217849.
研究表明，身心运动项目对认知能力下降的老年人的认知结果有有益影响。然而，很少有研究直接比较身心运动的具体方法，或研究远程项目实施的影响。
在一项针对认知障碍老年人的三臂随机对照试验（RCT）中，我们将一种强调运动、身体意识、个人意义和社会联系的多领域身心项目，以及一种中国传统身心运动（太极拳）与健康和健康教育对照条件进行比较。所有三种干预措施均通过远程方式每周进行两次（每次一小时），为期12周。两种积极干预措施通过直播进行。在干预前、干预后和干预后6个月对结果进行评估。共同主要结果是阿尔茨海默病评估量表 - 认知子量表（ADAS-cog）的变化以及默认模式网络（DMN）中的脑功能连接性。次要结果包括特定认知领域（如执行功能、注意力）的测量、 mobility、以及总体幸福感、生活质量、社会参与、自我调节和注意力调节的自我报告测量。
这项随机对照试验将直接比较两种身心运动项目与一种在12周内通过远程提供的教育对照措施对认知、神经影像学和参与者报告结果的影响。如果成功，这些项目可能为减缓认知衰退提供可扩展的策略，这有可能在某些个体中延迟痴呆症的发病。
NCT05217849。
